Molecular structure of Topotecan Hydrochloride, CAS Number: 119413-54-6
Topotecan Hydrochloride (CAS 119413-54-6)
See product citations (2)
Application:
Topotecan Hydrochloride is a water-soluble inhibitor of DNA Topo I
CAS Number:
119413-54-6
Purity:
≥98%
Molecular Weight:
457.9
Molecular Formula:
C23H23N3O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Topotecan Hydrochloride, in its water-soluble hydrochloride salt form, is a potent inhibitor of topoisomerase 1 (Topo I) that exerts proapoptotic and antiproliferative effects. By inhibiting the activity of topoisomerase I, topotecan hydrochloride effectively hinders DNA replication, leading to cellular demise. Derived from the natural alkaloid camptothecin (sc-200871), topotecan is a semisynthetic derivative. It is recognized for its ability to stabilize topoisomerase I/DNA cleavable complexes and induce rapid apoptotic cell death.
Topotecan Hydrochloride (CAS 119413-54-6) References
- Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues. | Arun, B. and Frenkel, EP. 2001. Expert Opin Pharmacother. 2: 491-505. PMID: 11336601
- A study of variable hydration states in topotecan hydrochloride. | Vogt, FG., et al. 2006. J Pharm Biomed Anal. 40: 1080-8. PMID: 16242889
- Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. | Kingsbury, WD., et al. 1991. J Med Chem. 34: 98-107. PMID: 1846923
- Topotecan hydrochloride effects on retinal vessels in newborn rats. | Pescosolido, N., et al. 2012. Histol Histopathol. 27: 497-506. PMID: 22374727
- Anticancer activities of genistein-topotecan combination in prostate cancer cells. | Hörmann, V., et al. 2012. J Cell Mol Med. 16: 2631-6. PMID: 22452992
- Combined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma. | Ghassemi, F., et al. 2014. JAMA Ophthalmol. 132: 936-41. PMID: 24789622
- Topotecan-tamoxifen duple PLGA polymeric nanoparticles: investigation of in vitro, in vivo and cellular uptake potential. | Khuroo, T., et al. 2014. Int J Pharm. 473: 384-94. PMID: 25051112
- Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor. | Tan, H., et al. 2015. Bioorg Med Chem. 23: 118-25. PMID: 25481395
- Development and evaluation of topotecan loaded solid lipid nanoparticles: A study in cervical cancer cell lines. | Chen, ZJ., et al. 2016. J Photochem Photobiol B. 165: 182-188. PMID: 27816641
- Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma. | Paez-Escamilla, M., et al. 2017. JAMA Ophthalmol. 135: 1453-1454. PMID: 29098282
- A Novel Polymer-Lipid Hybrid Nanoparticle for the Improvement of Topotecan Hydrochloride Physicochemical Properties. | Silva, EJ., et al. 2018. Curr Drug Deliv. 15: 979-986. PMID: 29243576
- Formulation and optimization of topotecan nanoparticles: In vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes. | Padhi, S., et al. 2018. J Photochem Photobiol B. 183: 222-232. PMID: 29729631
- In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells. | Uckun, FM., et al. 1995. Blood. 85: 2817-28. PMID: 7742543
Inhibitor of:
4930547C10Rik, COL4A6, CYP26A1, HIF-3α, PCDHGA4, RuvC, TEX264, Topo I, Topo IIIβ, and XPG.Activator of:
SSBP3, SSX3, TDP2, and ZBTB4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Topotecan Hydrochloride, 1 mg | sc-204919 | 1 mg | $44.00 | |||
Topotecan Hydrochloride, 5 mg | sc-204919A | 5 mg | $100.00 |