Molecular structure of Topotecan, CAS Number: 123948-87-8
Topotecan (CAS 123948-87-8)
Application:
Topotecan is a topo I inhibitor shown to stabilize topo I/DNA cleavable complexes
CAS Number:
123948-87-8
Molecular Weight:
421.4
Molecular Formula:
C23H23N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Topotecan is a potent inhibitor of Topo I (topoisomerase I), producing proapoptotic and antiproliferative effects. Topotecan is a semisynthetic derivative of the natural product alkaloid Camptothecin (sc-200871). Topotecan is described to stabilize topoisomerase I/DNA cleavable complexes and promote rapid apoptotic cell death in radiation-resistant human B-lineage acute lymphoblastic leukemia cells.
Topotecan (CAS 123948-87-8) References
- Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues. | Arun, B. and Frenkel, EP. 2001. Expert Opin Pharmacother. 2: 491-505. PMID: 11336601
- Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. | Kingsbury, WD., et al. 1991. J Med Chem. 34: 98-107. PMID: 1846923
- Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. | Taich, P., et al. 2016. PLoS One. 11: e0151343. PMID: 26959658
- Optimization of liposomal topotecan for use in treating neuroblastoma. | Chernov, L., et al. 2017. Cancer Med. 6: 1240-1254. PMID: 28544814
- Topotecan effect on the structure of normal and cancer plasma membrane lipid models: A multi-model approach. | Lopes-de-Araújo, J., et al. 2018. Eur J Pharm Sci. 123: 515-523. PMID: 30086354
- Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway. | Jin, J., et al. 2019. J Surg Res. 235: 83-92. PMID: 30691855
- Cytotoxic and Apoptotic Effects of Celecoxib and Topotecan on AGS and HEK 293 Cell Lines. | Badalanloo, K., et al. 2022. J Gastrointest Cancer. 53: 99-104. PMID: 33200341
- Oral delivery of topotecan in polymeric nanoparticles: Lymphatic distribution and pharmacokinetics. | Jeong, SH., et al. 2021. J Control Release. 335: 86-102. PMID: 34015399
- Dual-response electrochemical electrode for sensitive monitoring of topotecan and mitomycin as anticancer drugs in real samples. | Mehmandoust, M., et al. 2022. Chemosphere. 291: 132809. PMID: 34785182
- FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11. | Yin, YP., et al. 2022. Acta Pharmacol Sin. 43: 2119-2127. PMID: 34893686
- Clofarabine with topotecan, vinorelbine, and thiotepa reinduction regimen for children and young adults with relapsed AML. | Ramaswamy, K., et al. 2022. Blood Adv. 6: 2688-2694. PMID: 35008101
- Ocular and systemic toxicity of high-dose intravitreal topotecan in rabbits: Implications for retinoblastoma treatment. | Del Sole, MJ., et al. 2022. Exp Eye Res. 218: 109026. PMID: 35276184
- Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. | Munkuev, AA., et al. 2022. Molecules. 27: PMID: 35684313
- C60 Fullerene Clusters Stabilize the Biologically Inactive Form of Topotecan. | Buchelnikova, VA., et al. 2022. Chem Res Toxicol. 35: 1482-1492. PMID: 35980010
- In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells. | Uckun, FM., et al. 1995. Blood. 85: 2817-28. PMID: 7742543
Inhibitor of:
AI481877, APOBEC2, ARV1, Blood Group M antigen, C1QDC2, DCAR1, DYDC1, EXDL1, H1T2, HIF-1 alpha, LFY, LOC100039631, LOC439950, LOC643327, LOC644297, LOC645188, LOC645949, Mettl7a2-Higd1c, Mitochondrial Topo I, MSH2_Msh2, OBFC2B, OFCC1, Olr697, p63, PMS1, PNK, PSG9, REV1, RFPL3, RNGTT, SWAP, TDP1, Topo I, VCY1B, XRRA1, and ZBRK1.Activator of:
4930547C10Rik, DNA pol δ 2, EG194588, MCM5, ORC6, p400, PARP-8, Rad51D, and RPA 14 kDa subunit.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Topotecan, 100 mg | sc-338718 | 100 mg | $582.00 |