Molecular structure of Tomatidine hydrochloride, CAS Number: 6192-62-7
Tomatidine hydrochloride (CAS 6192-62-7)
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Alternate Names:
3β-Hydroxy-5 α-tomatidane hydrochloride
Application:
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine
CAS Number:
6192-62-7
Purity:
≥90%
Molecular Weight:
452.11
Molecular Formula:
C27H45NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to cyclopamine (sc-200929) but does not inhibit hedgehog pathway. It can be employed as a negative control for cyclopamine (sc-200929) and KAAD-cyclopamine. Tomatidine hydrochloride is a compound present in the skins and leaves of tomatoes. It exhibits the ability to inhibit NF-κB signaling in LPS-stimulated macrophages, thereby blocking the expression of inducible nitric oxide synthase (iNOS) and COX-2.
Tomatidine hydrochloride (CAS 6192-62-7) References
- Reversed-phase liquid chromatographic separation and simultaneous profiling of steroidal glycoalkaloids and their aglycones. | Kuronen, P., et al. 1999. J Chromatogr A. 863: 25-35. PMID: 10591461
- Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. | Watkins, DN., et al. 2003. Nature. 422: 313-7. PMID: 12629553
- Analysis of tomato glycoalkaloids by liquid chromatography coupled with electrospray ionization tandem mass spectrometry. | Cataldi, TR., et al. 2005. Rapid Commun Mass Spectrom. 19: 3103-10. PMID: 16200652
- Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. | Kawahara, T., et al. 2009. Anticancer Res. 29: 4629-32. PMID: 20032413
- Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus. | Chagnon, F., et al. 2014. Eur J Med Chem. 80: 605-20. PMID: 24877760
- Antiprotozoal Effects of the Tomato Tetrasaccharide Glycoalkaloid Tomatine and the Aglycone Tomatidine on Mucosal Trichomonads. | Liu, J., et al. 2016. J Agric Food Chem. 64: 8806-8810. PMID: 27934291
- Tomatidine, a novel antiviral compound towards dengue virus. | Diosa-Toro, M., et al. 2019. Antiviral Res. 161: 90-99. PMID: 30468746
- Tomatidine inhibits cell invasion through the negative modulation of gelatinase and inactivation of p38 and ERK. | Jeon, S. and Kim, MM. 2019. Chem Biol Interact. 313: 108826. PMID: 31545954
- Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro. | Troost, B., et al. 2020. Sci Rep. 10: 6364. PMID: 32286447
- Tomato roots secrete tomatine to modulate the bacterial assemblage of the rhizosphere. | Nakayasu, M., et al. 2021. Plant Physiol. 186: 270-284. PMID: 33619554
- Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi. | Rocha-Hasler, M., et al. 2021. Front Cell Infect Microbiol. 11: 617917. PMID: 33747979
- Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression. | Troost-Kind, B., et al. 2021. PLoS Negl Trop Dis. 15: e0009916. PMID: 34762680
- The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes. | Fujimaki, J., et al. 2022. Nutrients. 14: PMID: 35267998
- α-Tomatine degradation to tomatidine by food-related Aspergillus species belonging to the section Nigri. | Hui, CW., et al. 2023. Biosci Biotechnol Biochem. 87: 663-671. PMID: 36941129
Inhibitor of:
eIF1, eIF4G, and HHAT.Activator of:
DZIP1L, hedgehog, PTCHD4, and smoothened.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tomatidine hydrochloride, 25 mg | sc-200931 | 25 mg | $67.00 |