Molecular structure of Toltrazuril sulfoxide, CAS Number: 69004-15-5
Toltrazuril sulfoxide (CAS 69004-15-5)
CAS Number:
69004-15-5
Molecular Weight:
441.38
Molecular Formula:
C18H14F3N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Toltrazuril sulfoxide functions as a coccidiostat. It acts by inhibiting the enzyme dihydrofolate reductase in the protozoan parasite, leading to the disruption of folate metabolism. This disruption ultimately interferes with the synthesis of DNA, RNA, and proteins in the parasite, resulting in its death. At the molecular level, Toltrazuril sulfoxide targets the folate pathway in the parasite, disrupting its ability to replicate and survive. Toltrazuril Sulfoxide′s mechanism of action involves binding to the active site of dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. In this way, Toltrazuril sulfoxide plays a functional role in inhibiting the growth and proliferation of coccidian parasites in experimental applications.
Toltrazuril sulfoxide (CAS 69004-15-5) References
- The production and characterisation of an antibody to detect the coccidiostat toltrazuril and its metabolite ponazuril. | Connolly, L., et al. 2003. Analyst. 128: 459-61. PMID: 12790197
- Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. | Dirikolu, L., et al. 2009. J Vet Pharmacol Ther. 32: 280-8. PMID: 19646093
- Cerebrospinal fluid and blood concentrations of toltrazuril 5% suspension in the horse after oral dosing. | Furr, M. and Kennedy, T. 2000. Vet Ther. 1: 125-32. PMID: 19757559
- Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration. | Kim, MS., et al. 2010. Vet Parasitol. 169: 51-6. PMID: 20083354
- Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. | Lim, JH., et al. 2010. J Vet Med Sci. 72: 1085-7. PMID: 20332592
- Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry. | Ai, L., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 1757-63. PMID: 21565565
- Development of an analytical methodology for the determination of the antiparasitic drug toltrazuril and its two metabolites in surface water, soil and animal manure. | Olsen, J., et al. 2012. Anal Chim Acta. 755: 69-76. PMID: 23146396
- Simultaneous determination of toltrazuril and its metabolites in chicken and pig skin+fat by UPLC-UV method. | Zheng, W., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 972: 89-94. PMID: 25444542
- Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea. | Kang, J., et al. 2015. Food Addit Contam Part B Surveill. 8: 106-12. PMID: 25537072
- Pharmacokinetics of toltrazuril and its metabolites in pregnant and nonpregnant ewes and determination of their concentrations in milk, allantoic fluid, and newborn plasma. | Al-Qadri, RF., et al. 2020. J Vet Pharmacol Ther. 43: 339-346. PMID: 32067240
- Cystoisospora suis merozoite development assay for screening of drug efficacy in vitro. | Joachim, A. and Ruttkowski, B. 2021. Exp Parasitol. 220: 108035. PMID: 33189737
- Pharmacokinetics of toltrazuril and its metabolites after oral and parenteral administration of novel oil-based suspension based on micro-environmental pH-modifying solid dispersion in rabbits. | Xu, X., et al. 2021. Vet Parasitol. 299: 109580. PMID: 34597913
- Migration and toxicity of toltrazuril and its main metabolites in the environment. | Huo, M., et al. 2022. Chemosphere. 302: 134888. PMID: 35561774
- Microenvironment pH modified solid dispersion of Toltrazuril as a new strategy to improve the treatment of experimental Apicomplexan infection. | Sun, W., et al. 2023. Acta Trop. 238: 106797. PMID: 36528088
- Stereoselective S-oxygenation of an aryl-trifluoromethyl sulfoxide to the corresponding sulfone by rat liver cytochromes P450. | Benoit, E., et al. 1993. Biochem Pharmacol. 46: 2337-41. PMID: 8274166
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Toltrazuril sulfoxide, 50 mg | sc-237126 | 50 mg | $629.00 |