Date published: 2025-12-5

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Toltrazuril sulfone (CAS 69004-04-2)

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Alternate Names:
Ponazuril
Application:
Toltrazuril sulfone is an antiprotozoal
CAS Number:
69004-04-2
Purity:
≥98%
Molecular Weight:
457.38
Molecular Formula:
C18H14F3N3O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Toltrazuril sulfone, a chemical compound of interest in scientific research, has been a subject of investigation for its intriguing biological activities and potential applications. One prominent aspect of its mechanism of action is its efficacy against protozoan parasites, particularly those belonging to the genus Eimeria. Toltrazuril sulfone disrupts the development of these parasites by inhibiting mitochondrial function, ultimately leading to their death. Toltrazuril sulfone has been extensively studied for its anti-parasitic properties and mode of action. Researchers have explored its effects on parasite metabolism and cellular pathways, elucidating the biochemical mechanisms underlying its efficacy. Insights gained from these studies have contributed to our understanding of parasite biology and the development of novel strategies for controlling parasitic infections in animals. Furthermore, Toltrazuril sulfone′s anti-parasitic activity has sparked interest in its potential applications. Researchers have investigated its use in veterinary science, exploring its effectiveness in preventing and treating parasitic diseases in livestock and poultry. Additionally, Toltrazuril sulfone′s mechanism of action has led to its investigation in environmental microbiology, where it holds promise for controlling parasitic infections in aquatic ecosystems.


Toltrazuril sulfone (CAS 69004-04-2) References

  1. An explorative study to assess the efficacy of toltrazuril-sulfone (ponazuril) in calves experimentally infected with Neospora caninum.  |  Kritzner, S., et al. 2002. Ann Clin Microbiol Antimicrob. 1: 4. PMID: 12437777
  2. The production and characterisation of an antibody to detect the coccidiostat toltrazuril and its metabolite ponazuril.  |  Connolly, L., et al. 2003. Analyst. 128: 459-61. PMID: 12790197
  3. Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice.  |  Strohbusch, M., et al. 2009. Parasitol Res. 104: 1335-43. PMID: 19205743
  4. Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide.  |  Dirikolu, L., et al. 2009. J Vet Pharmacol Ther. 32: 368-78. PMID: 19614842
  5. Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle.  |  Dirikolu, L., et al. 2009. J Vet Pharmacol Ther. 32: 280-8. PMID: 19646093
  6. Cerebrospinal fluid and blood concentrations of toltrazuril 5% suspension in the horse after oral dosing.  |  Furr, M. and Kennedy, T. 2000. Vet Ther. 1: 125-32. PMID: 19757559
  7. Development of an analytical methodology for the determination of the antiparasitic drug toltrazuril and its two metabolites in surface water, soil and animal manure.  |  Olsen, J., et al. 2012. Anal Chim Acta. 755: 69-76. PMID: 23146396
  8. Cystoisospora suis merozoite development assay for screening of drug efficacy in vitro.  |  Joachim, A. and Ruttkowski, B. 2021. Exp Parasitol. 220: 108035. PMID: 33189737
  9. Risk of residues of toltrazuril sulfone in eggs after oral administration - Could setting maximum residue limit be helpful?  |  Pietruk, K., et al. 2021. Food Chem. 360: 130054. PMID: 34020367
  10. Pharmacokinetics of toltrazuril and its metabolite, toltrazuril sulfone, in suckling piglets following oral and intramuscular administrations.  |  Yeh, TW., et al. 2024. J Vet Pharmacol Ther. 47: 36-47. PMID: 37593974
  11. Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes.  |  Zapa, DMB., et al. 2024. Vet Parasitol Reg Stud Reports. 47: 100968. PMID: 38199704

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Toltrazuril sulfone, 10 mg

sc-237125
10 mg
$152.00