Tolnaftate (CAS 2398-96-1)

Tolnaftate, a synthetic thiocarbamate compound, has been extensively researched in scientific circles, particularly in the field of antifungal agents and dermatology. Researchers have delved into its mechanisms of action and its efficacy against various fungal pathogens, shedding light on its potential applications in combating fungal infections. One of the key mechanisms underlying tolnaftate′s antifungal activity is its inhibition of fungal squalene epoxidase, an enzyme crucial in the ergosterol biosynthesis pathway. Ergosterol is vital for fungal cell membranes, and its depletion disrupts membrane integrity and function, ultimately leading to fungal cell death. Studies have employed biochemical and molecular techniques to explain the interaction between tolnaftate and squalene epoxidase, providing insights into the structural basis of enzyme inhibition and the development of resistance mechanisms. Moreover, tolnaftate has shown broad-spectrum antifungal activity against various dermatophyte species, which commonly cause skin infections. Research efforts have focused on optimizing formulations and delivery systems to enhance the topical efficacy of tolnaftate and improve outcomes.