Molecular structure of Toll-Like Receptor 7 Ligand II, CAS Number: 226907-52-4
Toll-Like Receptor 7 Ligand II (CAS 226907-52-4)
Alternate Names:
TLR7 Ligand II; 9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine; 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
Application:
Toll-Like Receptor 7 Ligand II is a TLR7 agonist
CAS Number:
226907-52-4
Molecular Weight:
315.33
Molecular Formula:
C15H17N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Toll-Like Receptor 7 Ligand II is a cell-permeable hydroxyadenine compound which acts as a potent and highly specific TLR7 (toll-like receptor 7) agonist without any detectable activity towards TLR2/3/5/8/9. It is shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro .
Toll-Like Receptor 7 Ligand II (CAS 226907-52-4) References
- Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. | Kurimoto, A., et al. 2004. Bioorg Med Chem. 12: 1091-9. PMID: 14980621
- Activation of anti-hepatitis C virus responses via Toll-like receptor 7. | Lee, J., et al. 2006. Proc Natl Acad Sci U S A. 103: 1828-33. PMID: 16446426
- Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. | Jin, G., et al. 2006. Bioorg Med Chem Lett. 16: 4559-63. PMID: 16784848
- Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. | Hayashi, T., et al. 2008. Am J Physiol Regul Integr Comp Physiol. 295: R123-32. PMID: 18480244
- An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. | Dharmapuri, S., et al. 2009. Cancer Gene Ther. 16: 462-72. PMID: 18989354
- Comparison of rat and human responses to toll-like receptor 7 activation. | Clarke, S., et al. 2009. J Interferon Cytokine Res. 29: 113-26. PMID: 19014333
- Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. | Hayashi, T., et al. 2009. Proc Natl Acad Sci U S A. 106: 2764-9. PMID: 19188597
- Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice. | Benson, N., et al. 2010. Antimicrob Agents Chemother. 54: 1179-85. PMID: 20028817
- Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. | Russo, C., et al. 2011. Blood. 117: 5683-91. PMID: 21487111
- Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. | Hayashi, T., et al. 2012. PLoS One. 7: e45860. PMID: 23029281
- Plasmocytoid dendritic cell deficit of early response to toll-like receptor 7 agonist stimulation in multiple sclerosis patients. | Mycko, MP., et al. 2014. Clin Immunol. 153: 211-9. PMID: 24814238
- Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis. | Selmaj, I., et al. 2017. Ann Neurol. 81: 703-717. PMID: 28411393
- Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. | Bazin, HG., et al. 2020. Bioorg Med Chem Lett. 30: 126984. PMID: 32001135
Activator of:
TLR7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Toll-Like Receptor 7 Ligand II, 1 mg | sc-222360 | 1 mg | $260.00 |