Tolbutamide-d9 (CAS 1219794-57-6)

Tolbutamide-d9 is a deuterated form of tolbutamide, where nine of the hydrogen atoms are replaced with deuterium. This subtle isotopic modification is in research applications such as metabolic studies, where it serves as an ideal internal standard for mass spectrometry, improving the accuracy and precision of quantitative analyses. The deuterated atoms also enable the tracking of tolbutamide′s metabolic pathways and degradation products within biological systems. In addition, Tolbutamide-d9 is used in the study of enzyme kinetics, particularly with enzymes involved in chemical metabolism, to assess the impact of isotopic substitution on the rate of biotransformation. This research is important for elucidating the kinetics of tolbutamide and understanding the influence of deuterium on the stability and behavior of bioactive compounds. Moreover, the use of Tolbutamide-d9 can contribute to the development of more accurate and robust analytical methods for the detection and measurement of chemicals and their metabolites.