TOK-1β Antibody (B-10): sc-271985

TOK-1β Antibody (B-10) is a mouse monoclonal IgM antibody that detects TOK-1 beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TOK-1 beta antibody (B-10) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. TOK-1 protein plays a crucial role in cell cycle regulation, particularly at the G1/S transition, where TOK-1 protein interacts with the cyclin-dependent kinase (CDK) complex. This interaction helps modulate CDK activity, which is essential for cell division and proliferation. TOK-1 is alternatively spliced into two isoforms, TOK-1a and TOK-1b, which differ slightly in amino acid composition and functional properties. While both isoforms are expressed at the G1/S boundary, TOK-1a preferentially binds to an active form of CDK2 through p21, forming a ternary complex that enhances p21′s inhibitory effects on CDK2′s histone H1 kinase activity. TOK-1a may serve as a novel modulator of CDK2, providing insights into regulatory mechanisms governing the cell cycle. TOK-1′s ability to co-localize with p21 in the nucleus further underscores TOK-1′s significance in cell cycle control and highlights TOK-1′s potential as a target for therapeutic interventions in diseases characterized by dysregulated cell proliferation.

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TOK-1β Antibody (B-10) References:

1. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1.  |  Luo, Y., et al. 1995. Nature. 375: 159-61. PMID: 7753174
2. Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle.  |  Hengstschläger, M., et al. 1999. Mutat Res. 436: 1-9. PMID: 9878675

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TOK-1β Antibody (B-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TOK-1β Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TOK-1β Antibody (B-10) Specifications

Alternate Product Name: TOK-1β

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids: 271-301

Epitope Target: TOK-1β

Epitope Species: human

Product Reactivity/Detection: TOK-1β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TOK-1β Antibody (B-10): P: Blocking Peptide