Molecular structure of Tofisopam, CAS Number: 22345-47-7
Tofisopam (CAS 22345-47-7)
Application:
Tofisopam is a GABAA receptor ligand and modulator
CAS Number:
22345-47-7
Purity:
≥99%
Molecular Weight:
382.45
Molecular Formula:
C22H26N2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A ligand for the GABAA receptor benzodiazepine modulatory site.
Tofisopam (CAS 22345-47-7) References
- The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. | Rundfeldt, C., et al. 2010. J Neural Transm (Vienna). 117: 1319-25. PMID: 20967473
- Pharmacological Characteristics of Anxiolytics on Acetylcholine-Induced Contractions in Rat Detrusor Smooth Muscle. | Obara, K., et al. 2020. Pharmacology. 105: 369-376. PMID: 31655826
- Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats. | Üçel, Uİ., et al. 2020. Pharmacol Biochem Behav. 190: 172858. PMID: 31981560
- Vasorelaxant effects of benzodiazepines, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries. | Kagota, S., et al. 2021. Eur J Pharmacol. 892: 173744. PMID: 33220270
- Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus. | Watanabe, K., et al. 2021. Peptides. 145: 170623. PMID: 34375685
- Antioxidant Activity and Cytotoxicity against Cancer Cell Lines of the Extracts from Novel Xylaria Species Associated with Termite Nests and LC-MS Analysis. | Wangsawat, N., et al. 2021. Antioxidants (Basel). 10: PMID: 34679692
- Antidepressant-like effect of tofisopam in mice: A behavioural, molecular docking and MD simulation study. | Turan Yücel, N., et al. 2022. J Psychopharmacol. 36: 819-835. PMID: 35638175
- A New Strategy for Efficient Retrospective Data Analyses for Designer Benzodiazepines in Large LC-HRMS Datasets. | Pan, M., et al. 2022. Front Chem. 10: 868532. PMID: 35692684
- Distribution of neuromedin U (NMU)-like immunoreactivity in the goldfish brain, and effect of intracerebroventricular administration of NMU on emotional behavior in goldfish. | Matsuda, K., et al. 2022. Peptides. 156: 170846. PMID: 35905944
- The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. | Manchester, KR., et al. 2022. Forensic Toxicol. 40: 349-356. PMID: 36454409
- Assessing Chronodisruption Distress in Goldfish: The Importance of Multimodal Approaches. | Saiz, N., et al. 2023. Animals (Basel). 13: PMID: 37570290
- Electrophysiological Assessment of Newly Synthesized 2,3-Benzodiazepine Derivatives for Inhibiting the AMPA Receptor Channel. | Qneibi, M., et al. 2023. Molecules. 28: PMID: 37630319
- Autoradiographic localization and quantitative determination of specific binding sites of anxiolytic homophthalazines (formerly called 2,3-benzodiazepines) in the striato-pallido-nigral system of rats. | Horváth, EJ., et al. 1994. Brain Res Mol Brain Res. 22: 211-8. PMID: 8015381
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tofisopam, 10 mg | sc-253708 | 10 mg | $87.00 |