Molecular structure of Tobramycin sulphate, CAS Number: 49842-07-1
Tobramycin sulphate (CAS 49842-07-1)
Alternate Names:
Nebcin
Application:
Tobramycin sulphate is an aminoglycoside antibiotic with an efficacy against gram-bacteria
CAS Number:
49842-07-1
Molecular Weight:
565.59
Molecular Formula:
C18H37N5O9•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tobramycin sulphate is an aminoglycoside antibiotic with bactericidal action against a number of gram-negative bacteria. It works by inhibiting the growth of bacterial cells by binding to the 30S ribosomal subunit and blocking the formation of peptide bonds. This prevents the bacteria from synthesizing proteins, which is essential for their growth and survival. In addition, Tobramycin sulphate may act to inhibit the activity of certain enzymes, such as DNA polymerase and topoisomerase. It has also been used in laboratory experiments as a reagent in biochemical and physiological studies.
Tobramycin sulphate (CAS 49842-07-1) References
- Comparison of tobramycin nephrotoxicity in young adult and aged female rats. | Peters-Volleberg, GW., et al. 1999. Pharmacol Toxicol. 84: 147-53. PMID: 10227064
- Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material. | Wahl, P., et al. 2011. Arch Orthop Trauma Surg. 131: 657-62. PMID: 20938669
- Elution profiles of tobramycin and vancomycin from high-purity calcium sulphate beads incubated in a range of simulated body fluids. | Cooper, JJ., et al. 2016. J Biomater Appl. 31: 357-65. PMID: 27511982
- Evaluation of nephrotoxic and ototoxic effects of tobramycin in worldwide study. | Bendush, CL., et al. 1977. Med J Aust. 2: 22-6. PMID: 304521
- Investigating The Retention Potential of Chitosan Nanoparticulate Gel: Design, Development, In Vitro & Ex Vivo Characterization. | Kaul, S., et al. 2020. Recent Pat Antiinfect Drug Discov. 15: 41-67. PMID: 31612834
- Ecotoxicological study of six drugs in Aliivibrio fischeri, Daphnia magna and Raphidocelis subcapitata. | Lomba, L., et al. 2020. Environ Sci Pollut Res Int. 27: 9891-9900. PMID: 31925696
- [Toxicity of tobramycin in single and multiple administrations to laboratory animals]. | Gol'dberg, LE., et al. 1979. Antibiotiki. 24: 60-7. PMID: 426496
- Tobramycin ototoxicity. Repeated courses of high dosage treatment in children with cystic fibrosis. | Thomsen, J., et al. 1979. J Antimicrob Chemother. 5: 257-60. PMID: 479061
- [Use of a single daily dose of tobramycin sulfate for the prevention of infections caused by the positioning of fixed drains in body cavities]. | Pessione, E., et al. 1984. Minerva Med. 75: 463-8. PMID: 6709222
- Penetration of tobramycin sulphate into the human eye. | Petounis, A., et al. 1978. Br J Ophthalmol. 62: 660-2. PMID: 708683
- Pharmacokinetics of tobramycin in the camel. | Hadi, AA., et al. 1994. J Vet Pharmacol Ther. 17: 48-51. PMID: 8196094
- Teicoplanin versus vancomycin in the empirical treatment of febrile neutropenic patients. | Chow, AW., et al. 1993. Eur J Haematol Suppl. 54: 18-24. PMID: 8365461
- The efficacy of calcium gluconate in ocular hydrofluoric acid burns. | Beiran, I., et al. 1997. Hum Exp Toxicol. 16: 223-8. PMID: 9154448
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tobramycin sulphate, 500 mg | sc-264436 | 500 mg | $289.00 | |||
Tobramycin sulphate, 1 g | sc-264436A | 1 g | $500.00 |