Date published: 2025-9-5

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Tobramycin sulfate (CAS 79645-27-5)

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Application:
Tobramycin sulfate is an aminoglycoside antibiotic
CAS Number:
79645-27-5
Purity:
≥98%
Molecular Weight:
467.51 (free base basis)
Molecular Formula:
C18H37N5O9•xH2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tobramycin Sulfate is an aminoglycoside antibiotic that functions by binding to the 30S subunit of bacterial ribosomes, thereby inhibiting protein synthesis. This interference with protein production ultimately leads to the disruption of bacterial growth and reproduction. Tobramycin Sulfate works by causing misreading of the genetic code during translation, resulting in the production of nonfunctional or toxic peptides. This mechanism of action effectively hinders the ability of bacteria to proliferate and cause infection. By targeting the bacterial ribosomes, Tobramycin Sulfate disrupts the process of protein synthesis, ultimately leading to the inhibition of bacterial growth. This antibiotic′s mechanism of action at the molecular level may be for studying bacterial protein synthesis and understanding the mechanisms of antibiotic resistance.


Tobramycin sulfate (CAS 79645-27-5) References

  1. Ototoxicity of tobramycin sulfate.  |  Prazma, J., et al. 1976. Laryngoscope. 86: 259-68. PMID: 1053373
  2. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets.  |  Nelson, CL., et al. 2002. J Orthop Res. 20: 643-7. PMID: 12168649
  3. Stability of ceftazidime and tobramycin sulfate in peritoneal dialysis solution.  |  Mason, NA., et al. 1992. Am J Hosp Pharm. 49: 1139-42. PMID: 1595744
  4. Stability of gentamicin sulfate and tobramycin sulfate in extemporaneously prepared ophthalmic solutions at 8 degrees C.  |  McBride, HA., et al. 1991. Am J Hosp Pharm. 48: 507-9. PMID: 2028997
  5. Stability of parenteral solutions of tobramycin sulfate.  |  Bergstrom, RF., et al. 1975. Am J Hosp Pharm. 32: 887-8. PMID: 242216
  6. Purity determination of amphotericin B, colistin sulfate and tobramycin sulfate in a hydrophilic suspension by HPLC.  |  Pfeifer, C., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 990: 7-14. PMID: 25828728
  7. Moxalactam vs tobramycin-clindamycin. A randomized trial in secondary peritonitis.  |  Stellato, TA., et al. 1988. Arch Surg. 123: 714-7. PMID: 3285809
  8. Compatibility of clindamycin phosphate with amikacin sulfate at room temperature and with gentamicin sulfate and tobramycin sulfate under frozen conditions.  |  Marble, DA., et al. 1986. Drug Intell Clin Pharm. 20: 960-3. PMID: 3816545
  9. Stability of tobramycin sulfate in admixtures with calcium gluconate.  |  Nahata, MC. and Durrell, DE. 1985. Am J Hosp Pharm. 42: 1987-8. PMID: 3901742
  10. Tobramycin sulfate elimination in premature infants.  |  Arbeter, AM., et al. 1983. J Pediatr. 103: 131-5. PMID: 6864378
  11. Tobramycin sulfate: a summary of worldwide experience from clinical trials.  |  Bendush, CL. and Weber, R. 1976. J Infect Dis. 134 Suppl: S219-34. PMID: 787450
  12. Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use.  |  Brogden, RN., et al. 1976. Drugs. 12: 166-200. PMID: 789045
  13. Stability and antimicrobial activity of gentamicin sulfate, tobramycin sulfate and amikacin sulfate in polypropylene syringes for use in once-daily aminoglycoside therapy.  |  Mitrzyk, B., et al. 1996. Am J Health Syst Pharm. 53: 2855-9. PMID: 8957347

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tobramycin sulfate, 100 mg

sc-205865
100 mg
$63.00

Tobramycin sulfate, 500 mg

sc-205865A
500 mg
$219.00