TOAC is a nitroxide spin-labeled C α,α-disubstituted glycine derivative that is effective β-turn and 3(10)/α-helix promoter in peptides. It is a very good rigid electron paramagnetic resonance probe and fluorescence quencher.
1. Flippen-Anderson, J.L., et al. 1996. Int. J. Pept. Protein Res. 47: 231-238. PMID: 8738647 2. McNulty, J.C., et al. 2000. Biopolymers. 55: 479-485. PMID: 11304675 3. McSharry, J.J., et al. 1975. Virology. 67: 365-374. PMID: 1189285
Soluble in DMSO, 100% ethanol, acetone, and benzene. Insoluble in water.
Store at -20° C
>230° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Schreier S; et alSchreier S; et al. (PubMed ID: 22347893) howed that TOAC, a paramagnetic amino acid commonly used for studying the application of peptides, was successful in analyzing backbone dynamics and secondary structure. -SCBT Publication Review
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