Tns4 Antibody (3B8): sc-517073

Tns4 Antibody (3B8) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Tns4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Tns4 antibody (3B8) is available as the non-conjugated format. Tns4, also known as CTEN, is a 715 amino acid protein that plays a crucial role in cellular structure maintenance by anchoring actin filaments at focal adhesions through F-actin binding and capping activities. Tns4 is primarily localized to focal adhesions and is expressed in tissues such as the placenta and prostate. Tns4 contains a Src homology 2 (SH2) domain and a phosphatase tensin-type domain, which not only facilitate structural functions but also suggest involvement in signal transduction pathways. Post-translational modifications, including phosphorylation, can influence Tns4 activity and interactions. Down-regulation of Tns4 in prostate cancer cells indicates a potential role in tumor suppression, highlighting importance in both normal cellular functions and disease processes. By bridging the cytoskeleton and signaling pathways, Tns4 may be a key player in processes such as cartilage development, cell migration, and apoptosis, making Tns4 a valuable target for research in cancer biology and cellular dynamics.

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Tns4 Antibody (3B8) References:

1. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer.  |  Lo, SH. and Lo, TB. 2002. Cancer Res. 62: 4217-21. PMID: 12154022
2. Cten mRNA expression was correlated with tumor progression in lung cancers.  |  Sasaki, H., et al. 2003. Lung Cancer. 40: 151-5. PMID: 12711115
3. Cten mRNA expression is correlated with tumor progression in thymoma.  |  Sasaki, H., et al. 2003. Tumour Biol. 24: 271-4. PMID: 15001839
4. Cleavage of cten by caspase-3 during apoptosis.  |  Lo, SS., et al. 2005. Oncogene. 24: 4311-4. PMID: 15806167
5. Tensins: a new switch in cell migration.  |  Mouneimne, G. and Brugge, JS. 2007. Dev Cell. 13: 317-9. PMID: 17765673
6. Prognostic relevance of Tensin4 expression in human gastric cancer.  |  Sakashita, K., et al. 2008. Ann Surg Oncol. 15: 2606-13. PMID: 18612693
7. Tensin: a potential link between the cytoskeleton and signal transduction.  |  Lo, SH., et al. 1994. Bioessays. 16: 817-23. PMID: 7840759
8. Interactions of tensin with actin and identification of its three distinct actin-binding domains.  |  Lo, SH., et al. 1994. J Cell Biol. 125: 1067-75. PMID: 8195290
9. Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin.  |  Bockholt, SM. and Burridge, K. 1993. J Biol Chem. 268: 14565-7. PMID: 8325835