Tns3 Antibody (C-2): sc-376367
- Tns3 Antibody (C-2) is a mouse monoclonal IgG2a κ Tns3 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 721-1020 mapping within an internal region of Tns3 of human origin
- Tns3 Antibody (C-2) is recommended for detection of Tns3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Tns3 Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Tns3 Antibody (C-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Tns3 Antibody (C-2) (see ordering information below).
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Tns3 Antibody (C-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tns3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Tns3 (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tns3, also known as TEM6 or TENS1, plays a crucial role in cellular structure maintenance by anchoring actin filaments at focal adhesions, which is vital for cell adhesion and signaling. Tns3 is predominantly localized at focal adhesions of the plasma membrane and is essential for proper growth and development, as evidenced by growth retardation and mortality observed in Tns3-deficient mice. Tns3 shows high expression in thyroid and placenta, while maintaining presence in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle, and white blood cells. A Src homology 2 (SH2) domain in Tns3 suggests involvement in signal transduction pathways, linking cytoskeleton to cellular signaling mechanisms. These diverse functions and interactions of Tns3 highlight significance in both structural integrity and cellular communication, making anti-Tns3 antibody (C-2) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tns3 Antibody (C-2) References:
- Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. | Cui, Y., et al. 2004. Mol Cancer Res. 2: 225-32. PMID: 15140944
- Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. | Chiang, MK., et al. 2005. Dev Biol. 279: 368-77. PMID: 15733665
- Tensin3 is a novel thyroid-specific gene. | Maeda, I., et al. 2006. J Mol Endocrinol. 36: R1-8. PMID: 16461921
- Tensin: a potential link between the cytoskeleton and signal transduction. | Lo, SH., et al. 1994. Bioessays. 16: 817-23. PMID: 7840759
- Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin. | Chuang, JZ., et al. 1995. J Cell Biol. 128: 1095-109. PMID: 7896874
- Interactions of tensin with actin and identification of its three distinct actin-binding domains. | Lo, SH., et al. 1994. J Cell Biol. 125: 1067-75. PMID: 8195290
- Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. | Bockholt, SM. and Burridge, K. 1993. J Biol Chem. 268: 14565-7. PMID: 8325835
- The N-terminal domains of tensin and auxilin are phosphatase homologues. | Haynie, DT. and Ponting, CP. 1996. Protein Sci. 5: 2643-6. PMID: 8976573
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tns3 Antibody (C-2) | sc-376367 | 200 µg/ml | $322.00 | |||
Tns3 Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-529859 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tns3 Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-522929 | 200 µg Ab, 40 µg BP | $361.00 | |||
Tns3 Antibody (C-2): m-IgG2a BP-HRP Bundle | sc-547392 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tns3 Antibody (C-2) AC | sc-376367 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Tns3 Antibody (C-2) HRP | sc-376367 HRP | 200 µg/ml | $322.00 | |||
Tns3 Antibody (C-2) FITC | sc-376367 FITC | 200 µg/ml | $336.00 | |||
Tns3 Antibody (C-2) PE | sc-376367 PE | 200 µg/ml | $349.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 488 | sc-376367 AF488 | 200 µg/ml | $364.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 546 | sc-376367 AF546 | 200 µg/ml | $364.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 594 | sc-376367 AF594 | 200 µg/ml | $364.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 647 | sc-376367 AF647 | 200 µg/ml | $364.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 680 | sc-376367 AF680 | 200 µg/ml | $364.00 | |||
Tns3 Antibody (C-2) Alexa Fluor® 790 | sc-376367 AF790 | 200 µg/ml | $364.00 |