Molecular structure of TNP 470, CAS Number: 129298-91-5
TNP 470 (CAS 129298-91-5)
Alternate Names:
AGM 1470
Application:
TNP 470 is an analog of Fumagillin that displays potent antiangiogenic activity and inhibits MetAP2
CAS Number:
129298-91-5
Purity:
≥97%
Molecular Weight:
401.88
Molecular Formula:
C19H28CINO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TNP 470, is an analog of fumagillin, exhibits potent angiogenesis inhibition. Angiogenesis is the process by which new blood vessels form from pre-existing vessels. Angiogenesis is a mechanism in various physiological processes, but it also plays a significant role in the growth and metastasis of tumors. By irreversibly deactivating methionine aminopeptidase-2 (MetAP2) it effectively impedes endothelial cell proliferation in vitro and angiogenesis in vivo. MetAP2 is an enzyme involved in the regulation of endothelial cell proliferation and migration, which are key processes in angiogenesis. Notably, TNP 470 does not impact MetAP1 activity.
TNP 470 (CAS 129298-91-5) References
- TNP-470, a potent angiogenesis inhibitor, amplifies human T lymphocyte activation through an induction of nuclear factor-kappaB, nuclear factor-AT, and activation protein-1 transcription factors. | Locigno, R., et al. 2000. Lab Invest. 80: 13-21. PMID: 10652998
- TNP-470 inhibits intraabdominal adhesion formation. | Chiang, SC., et al. 2000. J Pediatr Surg. 35: 189-96. PMID: 10693664
- TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. | Yoshio, Y., et al. 2004. Kidney Int. 66: 1677-85. PMID: 15458466
- TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy. | Denton, MD., et al. 2004. Transplantation. 78: 1218-21. PMID: 15502723
- TNP-470 fails to block the onset of angiogenesis and early tumor establishment in an intravital minimal disease model. | Cernaianu, G., et al. 2006. Int J Colorectal Dis. 21: 143-54. PMID: 15937694
- TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells. | Wang, YQ., et al. 2006. Biochem Biophys Res Commun. 341: 239-44. PMID: 16413500
- Inhibitory effects of TNP-470 in combination with BCNU on tumor growth of human glioblastoma xenografts. | Yao, D., et al. 2010. J Huazhong Univ Sci Technolog Med Sci. 30: 757-61. PMID: 21181367
- The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice. | White, HM., et al. 2012. Obesity (Silver Spring). 20: 2003-9. PMID: 22510957
- TNP-470, a methionine aminopeptidase-2 inhibitor, inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro. | Kidoikhammouan, S., et al. 2012. Asian Pac J Cancer Prev. 13 Suppl: 155-60. PMID: 23480758
- TNP-470 Reduces Glioblastoma Angiogenesis in Three Dimensional GelMA Microwell Platform. | Nguyen, DT., et al. 2016. IEEE Trans Nanobioscience. 15: 683-688. PMID: 27542173
- TNP-470 skews DC differentiation to Th1-stimulatory phenotypes and can serve as a novel adjuvant in a cancer vaccine. | Ho, DH. and Wong, RH. 2018. Blood Adv. 2: 1664-1679. PMID: 30012585
- Blocking of methionine aminopeptidase-2 by TNP-470 induces apoptosis and increases chemosensitivity of cholangiocarcinoma. | Kidoikhammouan, S., et al. 2019. J Cancer Res Ther. 15: 148-152. PMID: 30880771
- The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin. | Craig, SL., et al. 2021. Biochem Pharmacol. 183: 114355. PMID: 33279496
- TNP-470 (a fungus-derived inhibitor of angiogenesis) reduces proliferation of cultured fibroblasts isolated from primary pterygia: a possible drug therapy for pterygia. | Kria, L., et al. 1998. Curr Eye Res. 17: 986-93. PMID: 9788301
Inhibitor of:
AAMP, Angiogenesis, Angptl1, ChM-I, CLEC-14A, Endomucin, Gm266, GTPBP6, Isthmin, MAD2_Mad2, MetAP-2, MFAP1, Multimerin-2, and Proliferin-4.Activator of:
EGFL6, MetAP-1, and neuropilin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNP 470, 10 mg | sc-296547 | 10 mg | $230.00 |