Molecular structure of TNF-α Antagonist III, R-7050, CAS Number: 303997-35-5
TNF-α Antagonist III, R-7050 (CAS 303997-35-5)
See product citations (11)
Alternate Names:
8-chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazo lo[4,3-a]quinoxaline
Application:
TNF-α Antagonist III, R-7050 is a cell-permeable triazoloquinoxaline compound that is a TNF-α receptor antagonist
CAS Number:
303997-35-5
Purity:
≥90%
Molecular Weight:
380.77
Molecular Formula:
C16H8ClF3N4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TNF-α Antagonist III, R-7050 is a cell-permeable triazoloquinoxaline compound that is reported to act as a TNF-alpha receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-alpha ligand-receptor binding. Additionally it may act to selectively inhibit TNF-alpha-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-alpha-induced than IL-1beta-induced NF-kappaB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
TNF-α Antagonist III, R-7050 (CAS 303997-35-5) References
- A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1. | Gururaja, TL., et al. 2007. Chem Biol. 14: 1105-18. PMID: 17961823
- Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse. | Wu, W. and Zhang, H. 2014. J Toxicol Sci. 39: 875-86. PMID: 25392278
- Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats. | Ma, Y., et al. 2015. Mol Med Rep. 12: 3095-100. PMID: 25955232
- Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease. | Mulay, SR., et al. 2017. J Am Soc Nephrol. 28: 761-768. PMID: 27612997
- Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice. | Zhong, B., et al. 2019. Curr Hypertens Rev. 15: 144-153. PMID: 30381083
- Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide. | Naime, ACA., et al. 2019. Platelets. 30: 1047-1052. PMID: 31076004
- KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. | Wen, Y., et al. 2019. J Am Soc Nephrol. 30: 1925-1938. PMID: 31337692
- Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats. | Ding, L., et al. 2019. J Transl Med. 17: 256. PMID: 31391086
- TNF Production in Activated RBL-2H3 Cells Requires Munc13-4. | Ayo, TE., et al. 2020. Inflammation. 43: 744-751. PMID: 31897916
- Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells. | Liu, J., et al. 2020. J Pain Res. 13: 1655-1664. PMID: 32753941
- Exploring the Molecular Mechanism of Cinnamic Acid-Mediated Cytotoxicity in Triple Negative MDA-MB-231 Breast Cancer Cells. | Pal, A., et al. 2021. Anticancer Agents Med Chem. 21: 1141-1150. PMID: 32767960
- TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke. | Lin, SY., et al. 2021. Antioxidants (Basel). 10: PMID: 34073455
- Microglia-derived TNF-α mediates Müller cell activation by activating the TNFR1-NF-κB pathway. | Ji, M., et al. 2022. Exp Eye Res. 214: 108852. PMID: 34801535
Inhibitor of:
TNF alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNF-α Antagonist III, R-7050, 1 mg | sc-356159A | 1 mg | $82.00 | |||
TNF-α Antagonist III, R-7050, 5 mg | sc-356159B | 5 mg | $101.00 | |||
TNF-α Antagonist III, R-7050, 10 mg | sc-356159 | 10 mg | $146.00 | |||
TNF-α Antagonist III, R-7050, 25 mg | sc-356159D | 25 mg | $317.00 | |||
TNF-α Antagonist III, R-7050, 50 mg | sc-356159C | 50 mg | $219.00 |