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TNF-α Antagonist III, R-7050 is a cell-permeable triazoloquinoxaline compound that is reported to act as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Additionally it has been shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
1. Gururaja, T.L., et al. 2007. Chem. Biol. 14: 1105-1118. PMID: 17961823
See how others have used TNF-α Antagonist III, R-7050. Click on the entry to view the PubMed entry .
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