Molecular structure of TNF-α Antagonist, CAS Number: 199999-60-5
TNF-α Antagonist (CAS 199999-60-5)
See product citations (8)
Alternate Names:
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH
Application:
TNF-α Antagonist is a cyclic peptide that mimics the most critical TNF recognition loop on TNF-R1
CAS Number:
199999-60-5
Molecular Weight:
1226.40
Molecular Formula:
C58H71N11O15S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
TNF-α Antagonist, also designated WP9QY is an exocyclic peptidomimetic that acts as a TNF-α antagonist by mimicking the most critical recognition loop on TNF receptor I, thus preventing interaction with the receptor. By blocking the TNFR ligand contact site, the peptide blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF. Useful for the development of small molecular inhibitors related to the prevention of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction. The designation WP9QY arises from the binding to the site observed in the TNF receptor complex.
TNF-α Antagonist (CAS 199999-60-5) References
- Costimulatory signals distinctively affect CD20- and B-cell-antigen-receptor-mediated apoptosis in Burkitt's lymphoma/leukemia cells. | Mimori, K., et al. 2003. Leukemia. 17: 1164-74. PMID: 12764385
- Enhanced TNF alpha and oxidative stress in patients with heart failure: effect of TNF alpha on platelet O2- production. | De Biase, L., et al. 2003. Thromb Haemost. 90: 317-25. PMID: 12888880
- Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. | Kojima, T., et al. 2005. J Med Dent Sci. 52: 91-9. PMID: 15868746
- A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice. | Suzuki, Y., et al. 2006. J Periodontal Res. 41: 81-91. PMID: 16499710
- A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. | Aoki, K., et al. 2006. J Clin Invest. 116: 1525-34. PMID: 16680194
- Developmental switch in the effects of TNFalpha on ventral midbrain dopaminergic neurons. | Doherty, GH. 2007. Neurosci Res. 57: 296-305. PMID: 17150272
- A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. | Saito, H., et al. 2007. Arthritis Rheum. 56: 1164-74. PMID: 17393436
- TNF-alpha antagonist therapy modify the tuberculin skin test response. | Cagatay, T., et al. 2011. Rheumatol Int. 31: 1147-51. PMID: 20349071
- TNF-α antagonist use and risk of hospitalization for infection in a national cohort of veterans with rheumatoid arthritis. | Lane, MA., et al. 2011. Medicine (Baltimore). 90: 139-145. PMID: 21358439
- TNF-α antagonist may not be suitable for severe rituximab-induced interstitial lung disease. | Tan, J. and Ni, X. 2015. J Clin Pharm Ther. 40: 249-50. PMID: 25809984
- Predictors of response to TNF-α antagonist therapy in Chinese rheumatoid arthritis. | Ding, R., et al. 2015. Clin Rheumatol. 34: 1203-10. PMID: 25990005
- TNF-alpha antagonist induced lupus on three different agents. | Mudduluru, BM., et al. 2017. Postgrad Med. 129: 304-306. PMID: 27748629
- Trivalent soluble TNF Receptor, a potent TNF-α antagonist for the treatment collagen-induced arthritis. | Cui, X., et al. 2018. Sci Rep. 8: 7327. PMID: 29743640
- TNF-α antagonist improves oxidative stress and lipid disorders induced by scorpion venom in the intestinal tissue. | Saidoune-Malek, I., et al. 2018. Acta Trop. 185: 307-313. PMID: 29909063
- Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF alpha binding to its receptor. | Takasaki, W., et al. 1997. Nat Biotechnol. 15: 1266-70. PMID: 9359109
Inhibitor of:
TNF alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNF-α Antagonist, 1 mg | sc-358755 | 1 mg | $277.00 |