Molecular structure of TN-16, CAS Number: 33016-12-5
TN-16 (CAS 33016-12-5)
See product citations (3)
Application:
TN-16 is an antitumor drug that blocks microtubule assembly
CAS Number:
33016-12-5
Purity:
≥97%
Molecular Weight:
306.36
Molecular Formula:
C19H18N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
TN-16 is blocks microtubule assembly by binding to the colchicine site of Tubulin. TN-16 prevents stabilization of microtubules in Paclitaxel-treated cells. The compound also blocks the cell cycle in M phase. TN-16 is a synthesized molecule that impedes the assembly and facilitates the disassembly of microtubules. It obstructs the b-TrCP-dependent degradation of the transcription factor Gli2, which consequently elevates the levels of BMP-2, highlighting the significance of microtubule assembly in biological functions.
TN-16 (CAS 33016-12-5) References
- The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. | Asoh, S., et al. 2000. J Biol Chem. 275: 37240-5. PMID: 10970895
- Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. | Kiso, T., et al. 2004. Antimicrob Agents Chemother. 48: 1739-48. PMID: 15105129
- Glucose regulated proteins 78 and 75 bind to the receptor for hyaluronan mediated motility in interphase microtubules. | Kuwabara, H., et al. 2006. Biochem Biophys Res Commun. 339: 971-6. PMID: 16329989
- Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers. | Barbier, P., et al. 2010. J Biol Chem. 285: 31672-81. PMID: 20675373
- Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach. | Canela, MD., et al. 2014. J Med Chem. 57: 3924-38. PMID: 24773591
- Predicting Molecular Targets for Small-Molecule Drugs with a Ligand-Based Interaction Fingerprint Approach. | Cao, R. and Wang, Y. 2016. ChemMedChem. 11: 1352-61. PMID: 26222196
- Moving toward a higher efficiency of microcell-mediated chromosome transfer. | Liskovykh, M., et al. 2016. Mol Ther Methods Clin Dev. 3: 16043. PMID: 27382603
- Microtubule disrupting agent-mediated inhibition of cancer cell growth is associated with blockade of autophagic flux and simultaneous induction of apoptosis. | Hasanain, M., et al. 2020. Cell Prolif. 53: e12749. PMID: 32167212
- Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction. | Foroutan, A., et al. 2023. Eur J Med Chem. 245: 114895. PMID: 36370553
- Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16. | Gupta, RS. 1986. Mol Pharmacol. 30: 142-8. PMID: 3736539
- The effect of TN-16 on the alkylation of tubulin. | Roach, MC. and Luduena, RF. 1985. Biochem Biophys Res Commun. 129: 200-5. PMID: 4004874
- Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. | Arai, T. 1983. FEBS Lett. 155: 273-6. PMID: 6852237
- Distribution of PCNA during postblastoderm cell division cycles in the Drosophila melanogaster embryo: effect of a string- mutation. | Yamaguchi, M., et al. 1995. Cell Struct Funct. 20: 47-57. PMID: 7796467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TN-16, 50 mg | sc-204347 | 50 mg | $117.00 |