TMX3 Antibody (G-5): sc-515248
- TMX3 Antibody (G-5) is a mouse monoclonal IgG1 κ TMX3 antibody provided at 200 µg/ml
- raised against amino acids 173-308 mapping within an internal region of TMX3 of human origin
- TMX3 Antibody (G-5) is recommended for detection of TMX3 of human and rat origin, and TXNDC10 of mouse origin by WB, IP, IF and ELISA
- Anti-TMX3 Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TMX3 Antibody (G-5) for WB applications. These reagents are now offered in bundles with TMX3 Antibody (G-5) (see ordering information below).
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TMX3 Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMX3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMX3 (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMX3 protein, also known as thioredoxin domain-containing protein 10, protein disulfide-isomerase TMX3, PDIA13, or TXNDC10, is a 454 amino acid single-pass endoplasmic reticulum membrane protein that plays a crucial role in proper protein folding within the cell. TMX3 belongs to the protein disulfide isomerase family and is characterized by the presence of a thioredoxin domain, which enables functioning as a dithiol oxidase and disulfide isomerase. This function is vital for maintaining cellular redox homeostasis and facilitating disulfide bond rearrangement, which is essential for structural integrity and functionality of many proteins. TMX3 is widely expressed in various tissues, with highest levels found in the eye, placenta, muscle, brain, testis, lung, uterus, kidney, stomach, prostate, bone, and liver, and is encoded by a gene located on human chromosome 18.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMX3 Antibody (G-5) References:
- Properties and biological activities of thioredoxins. | Powis, G. and Montfort, WR. 2001. Annu Rev Biophys Biomol Struct. 30: 421-55. PMID: 11441809
- Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. | Haugstetter, J., et al. 2005. J Biol Chem. 280: 8371-80. PMID: 15623505
- Thioredoxin and its related molecules: update 2005. | Nakamura, H. 2005. Antioxid Redox Signal. 7: 823-8. PMID: 15890030
- Thioredoxin - structural and functional complexity. | Stefanková, P., et al. 2005. Gen Physiol Biophys. 24: 3-11. PMID: 15900083
- Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain. | Haugstetter, J., et al. 2007. J Biol Chem. 282: 33859-33867. PMID: 17881353
- Structural and functional relations among thioredoxins of different species. | Eklund, H., et al. 1991. Proteins. 11: 13-28. PMID: 1961698
- Thioredoxin. | Holmgren, A. 1985. Annu Rev Biochem. 54: 237-71. PMID: 3896121
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMX3 Antibody (G-5) | sc-515248 | 200 µg/ml | $322.00 | |||
TMX3 Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-528010 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMX3 Antibody (G-5): m-IgG1 BP-HRP Bundle | sc-533383 | 200 µg Ab; 20 µg BP | $361.00 | |||
TMX3 Antibody (G-5) AC | sc-515248 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TMX3 Antibody (G-5) HRP | sc-515248 HRP | 200 µg/ml | $322.00 | |||
TMX3 Antibody (G-5) FITC | sc-515248 FITC | 200 µg/ml | $336.00 | |||
TMX3 Antibody (G-5) PE | sc-515248 PE | 200 µg/ml | $349.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 488 | sc-515248 AF488 | 200 µg/ml | $364.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 546 | sc-515248 AF546 | 200 µg/ml | $364.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 594 | sc-515248 AF594 | 200 µg/ml | $364.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 647 | sc-515248 AF647 | 200 µg/ml | $364.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 680 | sc-515248 AF680 | 200 µg/ml | $364.00 | |||
TMX3 Antibody (G-5) Alexa Fluor® 790 | sc-515248 AF790 | 200 µg/ml | $364.00 |