TMP-153 (CAS 128831-46-9)

TMP-153, a potent SOAT (acyl-CoA:cholesterol acyltransferase (ACAT)) inhibitor, may act to inhibit cholesterol esterification and reduce its influx into the plasma. In murine liver experiments, this compound has been reported to significantly reduce unesterified cholesterol content in addition to reducing the content of esterified cholesterol. Other studies have noted that TMP-153 is toxic to prion-infected neuronal (ScGT1) cells. ACAT inhibitors have demonstrated the ability to increase caspase-3 activity and prostaglandin E2 production in ScGT1 cells.This compound finds utility as an essential reagent in the realm of organic synthesis, a proficient catalyst fueling various chemical reactions, and a promising agent within the pharmaceutical domain. Displaying the form of a white crystalline solid, NCDQ exhibits a melting point spanning 138 to 140°C, coupled with a boiling point of 250 to 252°C. The molecular composition of NCDQ adheres to the formula C17H14ClF2N3O2, bestowing it with a molecular weight of 437.9g/mol.TMP-153 emerges as a pivotal component in the creation of diverse heterocyclic compounds like quinolines, pyrroles, and thiazoles. As a catalyst, its influence extends to fostering the synthesis of a wide array of organic entities, encompassing alkenes, amines, and alcohols.