Molecular structure of TMIO, CAS Number: 136440-22-7
TMIO (CAS 136440-22-7)
Alternate Names:
2,2,4-Trimethyl-2H-imidazole-1-oxide
Application:
TMIO is a selective, non-toxic, and cell permeable spin trap for peroxynitrite and secondary O-, C-, S-, & N- centered free radicals.
CAS Number:
136440-22-7
Purity:
≥98%
Molecular Weight:
126.2
Molecular Formula:
C6H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TMIO is a selective, cell permeable and non-toxic spin trap for peroxynitrite and secondary O-, C-, S-, and N- centered free radicals.
TMIO (CAS 136440-22-7) References
- Reassignment of organic peroxyl radical adducts. | Dikalov, SI. and Mason, RP. 1999. Free Radic Biol Med. 27: 864-72. PMID: 10515591
- Formation of Reactive Oxygen Species in Various Vascular Cells During Glyceryltrinitrate Metabolism. | Dikalov, S., et al. 1998. J Cardiovasc Pharmacol Ther. 3: 51-62. PMID: 10684481
- Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions. | Oettl, K., et al. 2004. Biochem Biophys Res Commun. 321: 379-85. PMID: 15358187
- Inhibition of Fe(2+)- and Fe(3+)- induced hydroxyl radical production by the iron-chelating drug deferiprone. | Timoshnikov, VA., et al. 2015. Free Radic Biol Med. 78: 118-22. PMID: 25451643
- Effective inhibition of copper-catalyzed production of hydroxyl radicals by deferiprone. | Timoshnikov, VA., et al. 2019. J Biol Inorg Chem. 24: 331-341. PMID: 30868263
- Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone. | Timoshnikov, VA., et al. 2020. Int J Mol Sci. 21: PMID: 32486511
- Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides. | Dikalov, S., et al. 1996. Biochem Biophys Res Commun. 218: 616-22. PMID: 8561805
- Determination of rate constants of the reactions of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches. | Dikalov, S., et al. 1996. Arch Biochem Biophys. 326: 207-18. PMID: 8611025
- Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides. | Krainev, AG., et al. 1996. J Magn Reson B. 111: 272-80. PMID: 8661292
- Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. | Dikalov, S., et al. 1997. Biochem Biophys Res Commun. 230: 54-7. PMID: 9020059
- Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3-carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants. | Dikalov, S., et al. 1997. Biochem Biophys Res Commun. 231: 701-4. PMID: 9070876
- Cytotoxicity of spin trapping compounds. | Haseloff, RF., et al. 1997. FEBS Lett. 418: 73-5. PMID: 9414098
- Revealing the Unexplored Mechanism of Photochemical Oxaziridine Conversion Process of 2H-imidazole 1-oxides | Sen, S., Sisodiya, D. S., Nikam, R., & Chattopadhyay, A. 2022. ChemistrySelect. 7(41): e202202371.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMIO, 50 mg | sc-205980 | 50 mg | $61.00 | |||
TMIO, 250 mg | sc-205980A | 250 mg | $191.00 |