TMCB CAS: 905105-89-7
MF: C11H9Br4N3O2
MW: 534.82
An inhibitor of both CK2 and MAPK15/ERK8.

TMCB (CAS 905105-89-7)

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Synonym: ERK8 Inhibitor I; Casein Kinase II Inhibitor VI
Application: An inhibitor of both CK2 and MAPK15/ERK8
CAS Number: 905105-89-7
Molecular Weight: 534.82
Molecular Formula: C11H9Br4N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).

TMCB has been shown to inhibit both casein kinase 2 (CK2) and MAPK15 (ERK8/extracellular-signal-regulated kinase 8) (IC50 = 0.50 μM for both CK2 and ERK8). In studies, TMCB has shown selectivity for CK2 over protein kinases which are normally affected by the casein kinase 2 inhibitors.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM).
Storage :
Store at room temperature
Boiling Point :
~588.8° C at 760 mmHg (Predicted)
Density :
~2.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
CK2: IC50 = 0.5 µM; ERK8: IC50 = 0.5 µM
Ki Data :
casein kinase IIα: Ki= 21 nM (human); CK2: Ki= 0.25 µM; PIM1: Ki= 8.65 µM; DYRK1a: Ki= 11.90 µM; HIPK2: Ki= 15.25 µM
pK Values :
pKb: 3.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46943415
MDL Number :
MFCD12195834
SMILES :
CN(C)C1=NC2=C(N1CC(=O)O)C(=C(C(=C2Br)Br)Br)Br

Download SDS (MSDS)

Certificate of Analysis

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