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TMCB has been shown to inhibit both casein kinase 2 (CK2) and MAPK15 (ERK8/extracellular-signal-regulated kinase 8) (IC50 = 0.50 μM for both CK2 and ERK8). In studies, TMCB has shown selectivity for CK2 over protein kinases which are normally affected by the casein kinase 2 inhibitors.
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