TM4SF4 Antibody (4E6): sc-293348

TM4SF4 Antibody (4E6) is a mouse monoclonal IgG2a kappa light chain antibody that detects TM4SF4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TM4SF4 antibody (4E6) is available as a non-conjugated format. TM4SF4, also known as intestine and liver tetraspan membrane protein (ILTMP), is a 202 amino acid multi-pass membrane protein that plays a crucial role in regulating density-dependent cell proliferation and the adhesive and proliferative states of intestinal epithelial cells. Located primarily in the jejunum and liver, TM4SF4 is a member of the transmembrane 4 superfamily, which is characterized by four hydrophobic domains that facilitate signal transduction. TM4SF4 undergoes post-translational N-linked glycosylation at two specific sites, a modification essential for growth inhibitory effects. TM4SF4 gene is mapped to human chromosome 3q25, highlighting significance in cellular processes and potential implications in various diseases.

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TM4SF4 Antibody (4E6) References:

1. Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.  |  Strack, S., et al. 2000. J Biol Chem. 275: 25061-4. PMID: 10827168
2. The L6 membrane proteins--a new four-transmembrane superfamily.  |  Wright, MD., et al. 2000. Protein Sci. 9: 1594-600. PMID: 10975581
3. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1).  |  Liu, Z., et al. 2001. Biochim Biophys Acta. 1518: 183-9. PMID: 11267677
4. Complexes of tetraspanins with integrins: more than meets the eye.  |  Berditchevski, F. 2001. J Cell Sci. 114: 4143-51. PMID: 11739647
5. Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180.  |  Quitsch, A., et al. 2005. J Neurosci. 25: 479-87. PMID: 15647492
6. Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.  |  Qiu, J., et al. 2007. J Hepatol. 46: 266-75. PMID: 17069928
7. Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome.  |  Qiao, J., et al. 2008. Reprod Biomed Online. 17: 425-35. PMID: 18765015
8. LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission.  |  Kravic, B., et al. 2016. J Neurochem. 139: 381-395. PMID: 27321929
9. Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology.  |  Stanika, R., et al. 2016. Sci Rep. 6: 34528. PMID: 27708393
10. A Sam68-dependent alternative splicing program shapes postsynaptic protein complexes.  |  Witte, H., et al. 2019. Eur J Neurosci. 49: 1436-1453. PMID: 30589479
11. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation.  |  Wice, BM. and Gordon, JI. 1995. J Biol Chem. 270: 21907-18. PMID: 7665614
12. Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines.  |  Ferrer, M., et al. 1998. Clin Exp Immunol. 113: 346-52. PMID: 9737661

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TM4SF4 Antibody (4E6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TM4SF4 Antibody (4E6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TM4SF4 Antibody (4E6) Specifications

Alternate Product Name: TM4SF4

Product Clone Name: 4E6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-202

Epitope Target: TM4SF4

Epitope Species: human

Product Reactivity/Detection: TM4SF4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TM4SF4 Antibody (4E6): N/A