Molecular structure of TLCK hydrochloride, CAS Number: 4238-41-9
TLCK hydrochloride (CAS 4238-41-9)
See product citations (2)
Alternate Names:
TLCK hydrochloride is also known as Tosyllysine Chloromethyl Ketone Hydrochloride.
Application:
TLCK hydrochloride is an active site-directed agent and irreversible inhibitor of trypsin-like serine proteases.
CAS Number:
4238-41-9
Purity:
≥95%
Molecular Weight:
369.3
Molecular Formula:
C14H21ClN2O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TLCK hydrochloride, or Tosyllysine Chloromethyl Ketone hydrochloride, is an active site-directed agent that irreversibly inhibits trypsin-like serine proteases such as granzyme D and tryptase. Cysteine proteinases and other enzymes may be inhibited by TLCK hydrochloride through non-selectively acting with thiol groups. To prevent proteolytic degradation, TLCK hydrochloride may be employed in protein purification protocols. It selectively inactivates clostripain obtained from C. histolyticum and inhibits other proteases including plasmin, thrombin, and papain and some kinases like PKC. TLCK hydrochloride inhibits LPS-induced expression of COX-2 in macrophages.
TLCK hydrochloride (CAS 4238-41-9) References
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- Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells. | Kitazumi, I., et al. 2010. FEBS J. 277: 404-12. PMID: 19968860
- Biochemical properties of anionic trypsin acting at high concentration of NaCl purified from the intestine of a carnivorous fish: smooth hound (Mustelus mustelus). | Bougatef, A., et al. 2010. J Agric Food Chem. 58: 5763-9. PMID: 20405833
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- Isolation and characterization of the histone variants in chicken erythrocytes. | Urban, MK., et al. 1979. Biochemistry. 18: 3952-60. PMID: 486404
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- Lipopolysaccharide-induced expression of cyclooxygenase-2 in mouse macrophages is inhibited by chloromethylketones and a direct inhibitor of NF-kappa B translocation. | Abate, A., et al. 1998. Prostaglandins Other Lipid Mediat. 56: 277-90. PMID: 9990673
Inhibitor of:
Granzyme, PKC, plasminogen, Protease, Ser/Thr Protein Kinase, Thrombin, Trypsin, and Tryptase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLCK hydrochloride, 200 mg | sc-201296 | 200 mg | $150.00 |