Molecular structure of TJU103, CAS Number: 10245-44-0
TJU103 (CAS 10245-44-0)
Alternate Names:
N′-(3H-Indol-3-ylidenemethyl)isonicotinohydrazide
Application:
TJU103 is an organic compound which blocks stable CD4-MHC class II binding
CAS Number:
10245-44-0
Molecular Weight:
264.28
Molecular Formula:
C15H12N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TJU103 is a non-peptidic, non-toxic organic compound that specifically blocks stable CD4-MHC class II binding. It also exhibits significant inhibition of immune response in animal models of autoimmune disease.
TJU103 (CAS 10245-44-0) References
- Monocyte rescue of human T cells from apoptosis is CD40/CD154 dependent. | Sakata, K., et al. 1999. Scand J Immunol. 50: 479-84. PMID: 10564550
- Coordinate suppression of superantigen-induced cytokine production and T-cell proliferation by a small nonpeptidic inhibitor of class II major histocompatibility complex and CD4 interaction. | Krakauer, T. 2000. Antimicrob Agents Chemother. 44: 1067-9. PMID: 10722514
- Mixed chimera converted into full donor chimera with powerful graft-versus-leukemia effects but no graft-versus-host disease after non T cell-depleted HLA-mismatched peripheral blood stem cell transplantation. | Wu, BY., et al. 2000. Bone Marrow Transplant. 26: 691-3. PMID: 11035376
- An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. | Edling, AE., et al. 2002. J Autoimmun. 18: 169-79. PMID: 11908949
- Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding. | Kawai, K., et al. 2003. J Allergy Clin Immunol. 112: 951-7. PMID: 14610487
- [Role of TJU103 in prevention of graft-versus-host disease after allogeneic stem cell transplantation in mice]. | Wang, SB., et al. 2006. Nan Fang Yi Ke Da Xue Xue Bao. 26: 810-3. PMID: 16793606
- Novel MOF-Derived Co@N-C Bifunctional Catalysts for Highly Efficient Zn-Air Batteries and Water Splitting. | Zhang, M., et al. 2018. Adv Mater. 30: PMID: 29349841
- [Blocking Two Signals of Immuno-Activated T Cells from Antigen Presenting Cells Can Prevent Chronic GVHD of Murine]. | Wu, YB., et al. 2018. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 26: 557-562. PMID: 29665932
- 14-3-3ζ-A Novel Immunogen Promotes Inflammatory Cytokine Production. | McGowan, J., et al. 2019. Front Immunol. 10: 1553. PMID: 31396202
- A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics. | Li, S., et al. 1997. Proc Natl Acad Sci U S A. 94: 73-8. PMID: 8990163
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TJU103, 10 mg | sc-222359 | 10 mg | $23.00 |