Tizanidine • HCl Tizanidine • HCl is a centrally acting α2-adrenergic (α2-AR) agonist.

Tizanidine • HCl (CAS 64461-82-1)

Tizanidine andbull HCl | CAS 64461-82-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride; Tizanidine hydrochloride
Application: Tizanidine • HCl is a centrally acting α2-adrenergic (α2-AR) agonist
CAS Number: 64461-82-1
Molecular Weight: 290.2
Molecular Formula: C9H8ClN5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tizanidine • HCl is a skeletal muscle relaxant and centrally acting α2-AR (α2-adrenergic) agonist. Displays affinity for the I1-imidazoline receptor and exhibits spasmolytic activity.


References

1. Piletz, J. E., et al. 1996. J. Pharmacol. Exp. Ther. 279: 694-702. PMID: 8930173

2. Coward, D.M. 1994. Neurology 44: 6-10. PMID: 797001

Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), methanol, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
280° C (lit.)
IC50 :
Antinociceptive upon epidural administration: IC50 = 48 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DK9910000
PubChem CID :
114869
Merck Index :
14: 9485
MDL Number :
MFCD00798231
SMILES :
C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gil et al Gil et al. (PubMed ID 19194166) found that the Alpha-1A receptor agonist, Tizanidine HCl, could counterbalance alpha-2 receptor agonist-induced analgesia in mice. -SCBT Publication Review
Date published: 2015-05-01
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