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Tiropramide Hydrochloride (CAS 53567-47-8)

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Alternate Names:
Alfospas; Maiorad; TiroMid
Application:
Tiropramide Hydrochloride is an antispasmodic agent
CAS Number:
53567-47-8
Molecular Weight:
504.10
Molecular Formula:
C28H41N3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tiropramide hydrochloride is a compound utilized mainly in the field of biochemical research. It is studied for its ability to interact with smooth muscle tissue, providing insights into the mechanisms of muscle contraction and relaxation under various experimental conditions. In vitro studies often employ tiopramide hydrochloride to understand the modulation of smooth muscle tone, which may be useful for investigating the fundamental aspects of muscle physiology. Additionally, the compound is of interest in the synthesis of analogs and derivatives that may exhibit different pharmacological profiles, which can be valuable for expanding the chemical space in non-medical research applications. Researchers also explore the molecular interactions between tiopramide hydrochloride and various receptors or ion channels, contributing to a broader understanding of its mechanisms at the cellular level.


Tiropramide Hydrochloride (CAS 53567-47-8) References

  1. Quantitative analysis of tiropramide in human blood by gas chromatography with nitrogen-phosphorus detector.  |  Kwon, OS., et al. 2003. Arch Pharm Res. 26: 416-20. PMID: 12785739
  2. Possible mechanisms of action of the antispasmodic agent tiropramide in the isolated detrusor from rats.  |  Uruno, T., et al. 1992. Jpn J Pharmacol. 60: 275-80. PMID: 1337131
  3. [Effects of tiropramide hydrochloride on the isolated detrusor and intravesical pressure of the bladder in situ in rats].  |  Uruno, T., et al. 1992. Nihon Yakurigaku Zasshi. 100: 329-38. PMID: 1446883
  4. Determination of tiropramide in human plasma by liquid chromatography-tandem mass spectrometry.  |  Lee, HW., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 796: 395-400. PMID: 14581078
  5. Enantioseparation of tiropramide by HPLC.  |  Ryoo, JJ., et al. 2004. Chirality. 16 Suppl: S51-4. PMID: 15239073
  6. Quantitative analysis of tiropramide in human plasma by gas chromatography coupled to mass spectrometry for application to a bioequivalence test.  |  Jhee, OH., et al. 2006. Clin Chim Acta. 366: 179-84. PMID: 16352299
  7. Use of sulfated cyclofructan 6 and sulfated cyclodextrins for the chiral separation of four basic pharmaceuticals by capillary electrophoresis.  |  Zhang, YJ., et al. 2013. Chirality. 25: 735-42. PMID: 23939835
  8. [Tiropramide hydrochloride in the premedication of diagnostic and therapeutic proctosigmoidocolonoscopy (endoscopic polypectomy) and the treatment of colonic diverticulosis].  |  De Masi, E. 1989. Minerva Med. 80: 587-90. PMID: 2747989
  9. Plasma concentration profile of tolterodine and 5-hydroxymethyl tolterodine following transdermal administration of tolterodine in rats.  |  Seok Ji, Y., et al. 2018. Pharmazie. 73: 375-378. PMID: 30001770
  10. Tiropramide and metabolites in blood and plasma after intravenous or peroral administration of 14C-tiropramide to the rat.  |  Setnikar, I., et al. 1988. Arzneimittelforschung. 38: 1815-9. PMID: 3245854
  11. Identification of metabolites of tiropramide in human urine.  |  Arigoni, R., et al. 1988. Biomed Environ Mass Spectrom. 15: 205-9. PMID: 3370360
  12. Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance.  |  Tidke, M., et al. 2023. Biomed Chromatogr. e5636. PMID: 37005769
  13. Mechanism of smooth muscle relaxation by tiropramide.  |  Vidal y Plana, RR., et al. 1981. J Pharm Pharmacol. 33: 19-24. PMID: 6114146

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tiropramide Hydrochloride, 5 mg

sc-391182A
5 mg
$100.00

Tiropramide Hydrochloride, 100 mg

sc-391182
100 mg
$290.00