TIP-1 Antibody (1H5): sc-517168

TIP-1 Antibody (1H5) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIP-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TIP-1 antibody (1H5) is available as the non-conjugated format. Tax interaction protein 1 (TIP-1), also known as Tax1-binding protein 3 or glutaminase-interacting protein 3, is a 124 amino acid protein primarily localized in the cytoplasm and nucleus, which is crucial for its role in cellular signaling pathways. TIP-1′s localization enables interaction with various signaling molecules, thereby influencing processes such as cell proliferation and differentiation. TIP-1 contains a PDZ domain that facilitates interactions with other proteins, including Rhotekin and β-catenin, which are essential for Rho-mediated activation of the FOS serum response element and the regulation of the Wnt signaling pathway, respectively. These interactions underscore TIP-1′s importance in modulating key cellular functions and highlight TIP-1′s potential as a target for therapeutic interventions in diseases where these pathways are dysregulated. TIP-1 has been detected in a variety of cell lines, including HeLa, and is weakly expressed in peripheral blood leukocytes, making TIP-1 a valuable tool for researchers studying its role in different biological contexts.

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TIP-1 Antibody (1H5) References:

1. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.  |  Reynaud, C., et al. 2000. J Biol Chem. 275: 33962-8. PMID: 10940294
2. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.  |  Olalla, L., et al. 2001. FEBS Lett. 488: 116-22. PMID: 11163757
3. Deregulation of cell-signaling pathways in HTLV-1 infection.  |  Hall, WW. and Fujii, M. 2005. Oncogene. 24: 5965-75. PMID: 16155603
4. Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2.  |  Park, HU., et al. 2006. Oncogene. 25: 438-47. PMID: 16158050
5. PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo.  |  Xie, L., et al. 2006. Blood. 107: 1980-8. PMID: 16263794
6. TIP-1 has PDZ scaffold antagonist activity.  |  Alewine, C., et al. 2006. Mol Biol Cell. 17: 4200-11. PMID: 16855024
7. Tip-1 induces filopodia growth and is important for gastrulation movements during zebrafish development.  |  Besser, J., et al. 2007. Dev Growth Differ. 49: 205-14. PMID: 17394599
8. Structural basis of beta-catenin recognition by Tax-interacting protein-1.  |  Zhang, J., et al. 2008. J Mol Biol. 384: 255-63. PMID: 18835279
9. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.  |  Rousset, R., et al. 1998. Oncogene. 16: 643-54. PMID: 9482110