TIN2 Antibody (4H262): sc-73177

TIN2 Antibody (4H262) is a mouse monoclonal IgG1 antibody that detects TIN2 protein of mouse, rat, and human origin by western blotting (WB). Anti-TIN2 antibody (4H262) is available as the non-conjugated format. TIN2 plays a crucial role in telomere maintenance, acting as a key component of the shelterin complex, which protects telomeres from DNA damage and regulates telomere length. This protection is vital for genomic stability, as dysfunctional telomeres can lead to chromosomal end-to-end fusions, genomic instability, and ultimately contribute to aging and cancer. TIN2 interacts with other telomeric proteins, including TRF1 and TRF2, to form a protective cap at chromosome ends, ensuring proper telomere maintenance during cell division. TIN2′s significance in telomere biology highlights potential therapeutic applications in diseases associated with telomere dysfunction.

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TIN2 Antibody (4H262) References:

1. TIN2, a new regulator of telomere length in human cells.  |  Kim, SH., et al. 1999. Nat Genet. 23: 405-12. PMID: 10581025
2. Identification of human Rap1: implications for telomere evolution.  |  Li, B., et al. 2000. Cell. 101: 471-83. PMID: 10850490
3. Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores.  |  Scherthan, H., et al. 2000. Mol Biol Cell. 11: 4189-203. PMID: 11102517
4. A protein-counting mechanism for telomere length regulation in yeast.  |  Marcand, S., et al. 1997. Science. 275: 986-90. PMID: 9020083
5. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.  |  Wotton, D. and Shore, D. 1997. Genes Dev. 11: 748-60. PMID: 9087429