Molecular structure of Timosaponin AIII, CAS Number: 41059-79-4
Timosaponin AIII (CAS 41059-79-4)
See product citations (3)
Application:
Timosaponin AIII is an inhibitor of mTORC1
CAS Number:
41059-79-4
Molecular Weight:
740.92
Molecular Formula:
C39H64O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50=10μM). The Timosaponin AIII cellular response has been found to be mediated via inhibition of mTORC1 and induction of ER stress (IC50 for BT474 cells=2.5µM and MDAMB231 cells=6µM). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Timosaponin AIII (CAS 41059-79-4) References
- Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. | Lim, SM., et al. 2015. Int Immunopharmacol. 25: 493-503. PMID: 25698557
- Metabolites characterization of timosaponin AIII in vivo and in vitro by using liquid chromatography-mass spectrometry. | Sun, Y., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 997: 236-43. PMID: 26134298
- Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. | Kim, KM., et al. 2016. Cancer Sci. 107: 181-8. PMID: 26595378
- Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells. | Wang, Y., et al. 2017. Arch Pharm Res. 40: 69-78. PMID: 27271334
- Timosaponin AIII: A novel potential anti-tumor compound from Anemarrhena asphodeloides. | Han, FY., et al. 2018. Steroids. 140: 125-130. PMID: 30296545
- Timosaponin AIII, a steroidal saponin, exhibits anti-tumor effect on taxol-resistant cells in vitro and in vivo. | Song, XY., et al. 2019. Steroids. 146: 57-64. PMID: 30951756
- Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo. | Zhou, ZY., et al. 2020. Acta Pharmacol Sin. 41: 260-269. PMID: 31515528
- Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE/MAPK signaling pathways. | Wang, N., et al. 2020. Phytomedicine. 75: 153247. PMID: 32502823
- Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review. | Lin, Y., et al. 2020. Front Pharmacol. 11: 764. PMID: 32581782
- Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways. | Zhang, M., et al. 2020. Front Pharmacol. 11: 601468. PMID: 33628174
- Novel Timosaponin AIII-Based Multifunctional Liposomal Delivery System for Synergistic Therapy Against Hepatocellular Carcinoma Cancer. | Zhang, L., et al. 2021. Int J Nanomedicine. 16: 5531-5550. PMID: 34429598
- Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma. | Li, X., et al. 2022. Comput Math Methods Med. 2022: 6756676. PMID: 35586672
- Blockage of Autophagy Increases Timosaponin AIII-Induced Apoptosis of Glioma Cells In Vitro and In Vivo. | Lee, CC., et al. 2022. Cells. 12: PMID: 36611961
- Timosaponin AIII Inhibits Migration and Invasion Abilities in Human Cervical Cancer Cells through Inactivation of p38 MAPK-Mediated uPA Expression In Vitro and In Vivo. | Chien, HJ., et al. 2022. Cancers (Basel). 15: PMID: 36612038
- Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. | Zhou, C., et al. 2023. Int J Biol Sci. 19: 1471-1489. PMID: 37056925
Inhibitor of:
mTOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Timosaponin AIII, 5 mg | sc-364636 | 5 mg | $194.00 |