TIF1β Antibody (23): sc-136102
- TIF1β Antibody (23) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 685-818 of TIF1β of mouse origin
- recommended for detection of TIF1β of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including canine; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TIF1β Antibody (23). This work is in progress.
TIF1β Antibody (23) is a mouse monoclonal IgG1 antibody that detects TIF1β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TIF1β, also known as transcriptional intermediary factor 1-beta, KAP1 (KRAB-associated protein 1), TF1β, and TRIM28 (tripartite motif-containing 28), plays a crucial role in transcriptional regulation by interacting with the Kruppel-associated box (KRAB) repression domain found in various transcription factors. This interaction is vital for mediating transcriptional repression, which is essential for processes such as cellular differentiation and response to stress. TIF1β is characterized by its unique structure, which includes three zinc-binding domains, a RING finger, B-boxes, and a coiled-coil domain, along with a Cys/His PHD finger and bromodomain that work together to facilitate its function. The human TIF1β gene is located on chromosome 19q13.4 and encodes an 835 amino acid nuclear protein, underscoring its importance in gene expression regulation and cellular homeostasis. Anti-TIF1β antibody (23) is an invaluable tool for researchers studying the intricate mechanisms of transcriptional control and its implications in various biological processes and diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIF1β Antibody (23) References:
- Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. | Cammas, F., et al. 2000. Development. 127: 2955-63. PMID: 10851139
- Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. | Cammas, F., et al. 2002. J Cell Sci. 115: 3439-48. PMID: 12154074
- Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski. | Nomura, T., et al. 2004. J Biol Chem. 279: 16715-26. PMID: 14761981
- Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1beta complex. | Satou, A., et al. 2004. FEBS Lett. 572: 211-5. PMID: 15304350
- TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. | Rambaud, J., et al. 2009. J Biol Chem. 284: 14147-56. PMID: 19321449
- The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells. | Miyagi, S., et al. 2014. Stem Cell Reports. 2: 145-52. PMID: 24527388
- O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β. | Resto, M., et al. 2016. J Biol Chem. 291: 22703-22713. PMID: 27601472
- O-GlcNAcase is an RNA polymerase II elongation factor coupled to pausing factors SPT5 and TIF1β. | Resto, M., et al. 2017. J Biol Chem. 292: 16524-16525. PMID: 28986433
- TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P. | Yamaguchi, R., et al. 2020. Cytokine. 134: 155180. PMID: 32673994
- TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia. | Morii, M., et al. 2024. Leukemia. 38: 1275-1286. PMID: 38734786
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIF1β Antibody (23) | sc-136102 | 50 µg/0.5 ml | $322.00 |