Molecular structure of Ticrynafen, CAS Number: 40180-04-9
Ticrynafen (CAS 40180-04-9)
Application:
Ticrynafen is a cytochrome P450 inhibitor
CAS Number:
40180-04-9
Purity:
>99%
Molecular Weight:
331.17
Molecular Formula:
C13H8Cl2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ticrynafen functions may have anti-inflammatory properties. It exerts its mechanism of action by inhibiting the activity of the enzyme cyclooxygenase, particularly the COX-1 and COX-2 isoenzymes. This inhibition leads to a decrease in the production of prostaglandins, which are lipid compounds involved in the inflammatory response. By reducing prostaglandin levels, Ticrynafen helps to alleviate inflammation and associated symptoms. Its mechanism of action involves binding to the active site of the cyclooxygenase enzyme, thereby preventing the conversion of arachidonic acid into prostaglandins.
Ticrynafen (CAS 40180-04-9) References
- The effects of ticrynafen in the rat. | Minor, S., et al. 1979. Res Commun Chem Pathol Pharmacol. 25: 53-63. PMID: 451359
- Pharmacokinetics and mode of action of tienilic acid. | Maass, AR., et al. 1982. Clin Exp Hypertens A. 4: 139-60. PMID: 7074982
- Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. | Manier, JW., et al. 1982. Am J Gastroenterol. 77: 401-4. PMID: 7091125
- Pharmacokinetic and pharmacodynamic studies of tienilic acid in healthy volunteers. | Kerremans, AL., et al. 1982. Eur J Clin Pharmacol. 22: 515-21. PMID: 7128663
- Nonsulfhydryl-reactive phenoxyacetic acids increase aqueous humor outflow facility. | Epstein, DL., et al. 1997. Invest Ophthalmol Vis Sci. 38: 1526-34. PMID: 9224280
Inhibitor of:
CYP.Substrate of:
CYP2C9, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ticrynafen, 10 mg | sc-220253 | 10 mg | $296.00 |