Molecular structure of Ticlopidine Hydrochloride, CAS Number: 53885-35-1
Ticlopidine Hydrochloride (CAS 53885-35-1)
See product citations (2)
Application:
Ticlopidine Hydrochloride is a platelet aggregation inhibitor
CAS Number:
53885-35-1
Purity:
≥99%
Molecular Weight:
300.25
Molecular Formula:
C14H14ClNS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ticlopidine hydrochloride is a compound that functions as an antiplatelet agent by inhibiting platelet aggregation. It achieves this by irreversibly blocking the P2Y12 subtype of ADP receptor on platelet cell membranes, thereby preventing the activation of the glycoprotein IIb/IIIa complex, which is necessary for fibrinogen binding and platelet aggregation. This mechanism of action ultimately leads to a reduction in the formation of blood clots. Ticlopidine hydrochloride binds to the P2Y12 receptor, preventing the conformational change necessary for signal transduction and platelet activation. This interference with platelet function is a key aspect of its mode of action.
Ticlopidine Hydrochloride (CAS 53885-35-1) References
- Effect of ticlopidine hydrochloride on erythropoietin-induced rise in blood pressure in patients on maintenance hemodialysis. | Kusano, E., et al. 2002. Nephron. 91: 654-8. PMID: 12138269
- Bioequivalence of ticlopidine hydrochloride administered in single dose to healthy volunteers. | Marzo, A., et al. 2002. Pharmacol Res. 46: 401-7. PMID: 12419644
- Pharmacokinetic and pharmacological interactions between ticlopidine hydrochloride and Kangen-Karyu - Chinese traditional herbal medicine. | Makino, T., et al. 2003. Phytother Res. 17: 1021-4. PMID: 14595580
- Patient characteristics in ticlopidine hydrochloride-induced liver injury: Case-control study. | Mizushima, M., et al. 2005. Hepatol Res. 33: 234-40. PMID: 16112897
- Increase in tumor oxygenation and potentiation of radiation effects using pentoxifylline, vinpocetine and ticlopidine hydrochloride. | Amano, M., et al. 2005. J Radiat Res. 46: 373-8. PMID: 16394626
- Quantitative determination of ticlopidine hydrochloride in human plasma by high-performance liquid chromatography-electronspray ionization mass spectrometry. | Sun, J., et al. 2009. Arzneimittelforschung. 59: 121-8. PMID: 19402342
- Development and validation of a stability indicating UPLC method for determination of ticlopidine hydrochloride in its tablet formulation. | Ram, V., et al. 2011. Saudi Pharm J. 19: 159-64. PMID: 23960754
- Drug-induced thrombotic microangiopathy using the Japanese pharmacovigilance database. | Niinomi, I., et al. 2020. Int J Clin Pharmacol Ther. 58: 543-549. PMID: 32631486
- RAID: Regression Analysis-Based Inductive DNA Microarray for Precise Read-Across. | Amano, Y., et al. 2022. Front Pharmacol. 13: 879907. PMID: 35935858
- Bleeding risk in patients with multiple myeloma treated for venous thromboembolism: a MarketScan analysis. | Adrianzen-Herrera, D., et al. 2023. Res Pract Thromb Haemost. 7: 100024. PMID: 36873562
- Frequency and clinical features of radiographic head injury caused by inpatient falls: a single-centre retrospective cohort study. | Tokioka, F., et al. 2023. BMJ Open. 13: e066426. PMID: 37094893
- Occurrence of intraocular hemorrhages under monotherapy or combination therapy of antiplatelets and anticoagulants using the Japanese Adverse Drug Event Report database. | Tanaka, J., et al. 2023. J Pharm Pharm Sci. 26: 11263. PMID: 37122387
- Ticlopidine hydrochloride and prevention of stroke. | Macko, R. 1993. West J Med. 159: 182. PMID: 8212686
Inhibitor of:
CES2, CYP1A2, CYP2A6, CYP2B1, CYP2B10, CYP2B13, CYP2B6, CYP2B9, CYP2C18, Cyp2c44, Cyp2c54, Cyp2c55, Cyp2c65, Cyp2c68, CYP2F1, CYP2J11, CYP2J12, CYP2J7, CYP2J8, CYP2S1, CYP39A1, CyPA, FMO2, FMO4, FMO5, FMO9, P2Y12, and VWF.Activator of:
AQP10, and DGS8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ticlopidine Hydrochloride, 1 g | sc-205861 | 1 g | $31.00 | |||
Ticlopidine Hydrochloride, 5 g | sc-205861A | 5 g | $97.00 |