Tianeptine Metabolite MC5 Sodium Salt (CAS 115220-11-6)
QUICK LINKS
Tianeptine Metabolite MC5 Sodium Salt is a primary metabolite of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake and is similar to amineptine. Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro. The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation counter.
Tianeptine Metabolite MC5 Sodium Salt (CAS 115220-11-6) References
- Analgesic effect of tianeptine in mice. | Uzbay, IT., et al. 1999. Life Sci. 64: 1313-9. PMID: 10227587
- High-performance liquid chromatographic determination of tianeptine in plasma applied to pharmacokinetic studies. | Gaulier, JM., et al. 2000. J Chromatogr B Biomed Sci Appl. 748: 407-14. PMID: 11087083
- Neuroprotective properties of tianeptine: interactions with cytokines. | Plaisant, F., et al. 2003. Neuropharmacology. 44: 801-9. PMID: 12681378
- HPLC-DAD determination of CNS-acting drugs in human blood, plasma, and serum. | Moreno, AM., et al. 2014. Crit Rev Anal Chem. 44: 68-106. PMID: 25391214
- Tianeptine and its main metabolite pharmacokinetics in chronic alcoholism and cirrhosis. | Royer, RJ., et al. 1989. Clin Pharmacokinet. 16: 186-91. PMID: 2721088
- The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor. | Samuels, BA., et al. 2017. Neuropsychopharmacology. 42: 2052-2063. PMID: 28303899
- Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method. | Szafarz, M., et al. 2018. Naunyn Schmiedebergs Arch Pharmacol. 391: 185-196. PMID: 29230490
- Neurochemical profile of tianeptine, a new antidepressant drug. | Kato, G. and Weitsch, AF. 1988. Clin Neuropharmacol. 11 Suppl 2: S43-50. PMID: 3052825
- Economic Spectrofluorometric Bioanalysis of Empagliflozin in Rats' Plasma. | Ayoub, B., et al. 2021. J Anal Methods Chem. 2021: 9983477. PMID: 34055450
- Tianeptine, a selective enhancer of serotonin uptake in rat brain. | Mennini, T., et al. 1987. Naunyn Schmiedebergs Arch Pharmacol. 336: 478-82. PMID: 3437921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tianeptine Metabolite MC5 Sodium Salt, 1 mg | sc-213045 | 1 mg | $373.00 |