Tianeptine Metabolite MC5-d4 Methyl Ester
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Tianeptine Metabolite MC5-d4 Methyl Ester is a deuterium-labeled intermediate of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake and is similar to amineptine. Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation counter.
Tianeptine Metabolite MC5-d4 Methyl Ester References
- Analgesic effect of tianeptine in mice. | Uzbay, IT., et al. 1999. Life Sci. 64: 1313-9. PMID: 10227587
- Neuroprotective properties of tianeptine: interactions with cytokines. | Plaisant, F., et al. 2003. Neuropharmacology. 44: 801-9. PMID: 12681378
- Neurochemical profile of tianeptine, a new antidepressant drug. | Kato, G. and Weitsch, AF. 1988. Clin Neuropharmacol. 11 Suppl 2: S43-50. PMID: 3052825
- Tianeptine, a selective enhancer of serotonin uptake in rat brain. | Mennini, T., et al. 1987. Naunyn Schmiedebergs Arch Pharmacol. 336: 478-82. PMID: 3437921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tianeptine Metabolite MC5-d4 Methyl Ester, 1 mg | sc-220248 | 1 mg | $320.00 |