Molecular structure of Tiamulin fumarate, CAS Number: 55297-96-6
Tiamulin fumarate (CAS 55297-96-6)
Alternate Names:
Thiamutilin fumarate
Application:
Tiamulin fumarate is an antibacterial and a derivative of Pleuromutilin
CAS Number:
55297-96-6
Molecular Weight:
609.81
Molecular Formula:
C28H47NO4S•C4H4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tiamulin fumarate is a compound that functions as a bacteriostatic agent by inhibiting protein synthesis in susceptible bacteria. It achieves this by binding to the 50S ribosomal subunit, specifically to the peptidyl transferase center, which results in the prevention of peptide bond formation during translation. This interference with protein synthesis ultimately leads to the inhibition of bacterial growth and reproduction. Tiamulin fumarate specifically targets Gram-positive bacteria, as well as certain mycoplasma and spirochetes, making it useful for studying the molecular mechanisms of protein synthesis and bacterial growth.
Tiamulin fumarate (CAS 55297-96-6) References
- Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety. | Yi, Y., et al. 2017. Eur J Med Chem. 126: 687-695. PMID: 27940400
- Routine Prophylactic Antimicrobial Use Is Associated with Increased Phenotypic and Genotypic Resistance in Commensal Escherichia coli Isolates Recovered from Healthy Fattening Pigs on Farms in Thailand. | Lugsomya, K., et al. 2018. Microb Drug Resist. 24: 213-223. PMID: 28604274
- Synthesis and Biological Activity Evaluation of Novel Heterocyclic Pleuromutilin Derivatives. | Yi, Y., et al. 2017. Molecules. 22: PMID: 28617344
- Antibacterial activity and pharmacokinetic profile of a promising antibacterial agent: 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin. | Shang, R., et al. 2018. Pharmacol Res. 129: 424-431. PMID: 29133214
- A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats. | Fu, Y., et al. 2019. Molecules. 24: PMID: 30813235
- Pharmacokinetics, bioavailability, and tissue disposal profiles of Tiamulin fumarate in Nile tilapia (Oreochromis niloticus) following oral and intravenous administrations. | Liu, Y., et al. 2021. J Vet Pharmacol Ther. 44: 590-602. PMID: 33675107
- In Vitro and In Vivo Activity of 14-O-[(4,6-Diamino-pyrimidine-2-yl) thioacetyl] Mutilin against Methicillin-Resistant Staphylococcus aureus. | Fu, Y., et al. 2021. Molecules. 26: PMID: 34071703
- Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis. | Xiang, R., et al. 2022. J Dermatol Sci. 107: 32-40. PMID: 35718680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tiamulin fumarate, 1 g | sc-213043 | 1 g | $332.00 |