Tiam1 Antibody (F-11): sc-377355
- Tiam1 Antibody (F-11) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of Tiam1 of mouse origin
- recommended for detection of Tiam1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See Tiam1 (E-7): sc-393315 for Tiam1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tiam1 Antibody (F-11). This work is in progress.
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Tiam1 Antibody (F-11) is a mouse monoclonal IgM antibody that detects Tiam1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tiam1 plays a crucial role in cellular signaling, particularly in the regulation of the Rho family of GTPases, which are essential for cytoskeletal dynamics and cell motility. Tiam1 contains both Dbl and Pleckstrin-homologous domains, which are characteristic of guanine nucleotide exchange factors that activate Rho-like proteins. This activation is vital for processes such as cell invasion and migration, making anti-Tiam1 antibody (F-11) a significant tool in cancer metastasis research. In fibroblasts, Tiam1 induces a phenotype akin to that of constitutively activated Rac1, leading to membrane ruffling, a hallmark of increased cell motility. Furthermore, the interaction of Tiam1 with Rac1 suggests that the Tiam1-Rac signaling pathway is integral to the invasive capabilities of tumor cells, highlighting Tiam1′s importance in understanding cancer progression and potential therapeutic targets. Anti-Tiam1 antibody (F-11) serves as a valuable tool for researchers investigating the mechanisms of cell invasion and the role of Rho GTPases in various biological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tiam1 Antibody (F-11) | sc-377355 | 200 µg/ml | $322.00 | |||
Tiam1 (F-11) Neutralizing Peptide | sc-377355 P | 100 µg/0.5 ml | $69.00 |