Date published: 2025-12-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

Thyroxine 4′-O-β-D-Glucuronide (CAS 21462-56-6)

0.0(0)
Write a reviewAsk a question

Alternate Names:
4-[4-[(2S)-2-Amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenyl β-D-Glucopyranosiduronic ccAcid; Levothyroxine Phenolic Glucuronide; (S)-4-[4-(2-Amino-2-carboxyethyl)-2,6-diiodophenoxy]-2,6-diiodophenyl β-D-Glucopyranosiduronic Acid; L-Thyroxine Glucuronide; Thyroxine Glucuronide
CAS Number:
21462-56-6
Molecular Weight:
952.99
Molecular Formula:
C21H19I4NO10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Thyroxine 4′-O-β-D-Glucuronide is a metabolite derivative of thyroxine, designed to explore and elucidate the complexities of thyroid hormone metabolism and regulation. Its unique structure, incorporating a glucuronic acid moiety, makes it an invaluable tool in the study of thyroxine′s biotransformation processes, particularly its phase II metabolism, where it undergoes conjugation, rendering the molecule more water-soluble and thus easier to excrete. This derivative plays a pivotal role in research focused on understanding the dynamics of thyroid hormone distribution and elimination, offering insights into the mechanisms governing hormonal homeostasis and the intricacies of endocrine system functions. By serving as a model compound, Thyroxine 4′-O-β-D-Glucuronide aids in the development of analytical techniques for detecting and quantifying hormone metabolites, further contributing to our knowledge of thyroid physiology and the metabolic pathways that modulate its activity within biological systems.


Thyroxine 4′-O-β-D-Glucuronide (CAS 21462-56-6) References

  1. The effect of bilirubin on the excretion of thyroxine in the bile of rats.  |  CUARON, A., et al. 1962. J Physiol. 163: 160-7. PMID: 13882551
  2. Effect of salicylate on the biliary excretion of thyroxine in rats.  |  OSORIO, C. and MYANT, NB. 1963. Endocrinology. 72: 253-8. PMID: 13940558
  3. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat.  |  Fisher, JW., et al. 2006. Toxicol Sci. 90: 87-95. PMID: 16339789
  4. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.  |  Lecureux, L., et al. 2009. Toxicol Sci. 108: 482-91. PMID: 19211616
  5. Deconjugation of thyroxine glucuronide by the rat kidney.  |  Hays, MT. 2009. Thyroid. 19: 1001-4. PMID: 19731980
  6. Is the kidney a major storage site for thyroxine as thyroxine glucuronide?  |  Buitendijk, M. and Galton, VA. 2012. Thyroid. 22: 187-91. PMID: 22175240
  7. Preparation and separation of the glucuronide and sulfate conjugates of thyroxine and triiodothyronine.  |  Hays, MT. and Hsu, L. 1987. Endocr Res. 13: 215-28. PMID: 2448134
  8. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia.  |  McClain, RM. 1989. Toxicol Pathol. 17: 294-306. PMID: 2675280
  9. The effect of phenobarbital on the metabolism and excretion of thyroxine in rats.  |  McClain, RM., et al. 1989. Toxicol Appl Pharmacol. 99: 216-28. PMID: 2734788
  10. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate.  |  Rutgers, M., et al. 1989. Endocrinology. 125: 2175-86. PMID: 2791984
  11. Distribution and fate of pharmaceuticals and their metabolite conjugates in a municipal wastewater treatment plant.  |  Brown, AK. and Wong, CS. 2018. Water Res. 144: 774-783. PMID: 30176575
  12. Insitu kinetics of human pharmaceutical conjugates and the impact of transformation, deconjugation, and sorption on persistence in wastewater batch bioreactors.  |  Brown, AK., et al. 2020. Environ Pollut. 265: 114852. PMID: 32480005
  13. Transport of thyroxine glucuronide into bile.  |  Hillier, AP. 1972. J Physiol. 227: 195-200. PMID: 4646576
  14. Excretion of the glucuronide of thyroxine in cat bile.  |  Myant, NB. 1966. Biochem J. 99: 341-6. PMID: 4957852
  15. Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene.  |  Goldstein, JA. and Taurog, A. 1968. Biochem Pharmacol. 17: 1049-65. PMID: 5661343

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thyroxine 4′-O-β-D-Glucuronide, 1 mg

sc-475008
1 mg
$347.00

Thyroxine 4′-O-β-D-Glucuronide, 2 mg

sc-475008A
2 mg
$627.00

Thyroxine 4′-O-β-D-Glucuronide, 5 mg

sc-475008B
5 mg
$1479.00