Molecular structure of Thyrotropin-Releasing Hormone, CAS Number: 24305-27-9
Thyrotropin-Releasing Hormone (CAS 24305-27-9)
Alternate Names:
TRH; Pyr-His-Pro-NH2; Protirelin; Rifathyroin; Thyroliberin; Lopremone; Thypinone
CAS Number:
24305-27-9
Molecular Weight:
362.38
Molecular Formula:
C16H22N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Thyrotropin-Releasing Hormone is a tripeptide hormone, known for its role in the regulation of the thyroid gland in biological applications. In biochemical research, Thyrotropin-Releasing Hormone is often used to study peptide-hormone interactions and their effects on signaling pathways. The hormone can be employed in experimental models to understand how peptide hormones influence cellular communication and physiological responses. Researchers utilize Thyrotropin-Releasing Hormone to explore the mechanisms of hormone action, particularly how peptides can influence cellular activity through receptor binding and subsequent signal transduction pathways.
Thyrotropin-Releasing Hormone (CAS 24305-27-9) References
- Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor. | Schiöth, HB., et al. 1999. Peptides. 20: 395-400. PMID: 10447100
- Thyrotropin releasing hormone decreases alcohol intake and preference in rats. | Kulkosky, PJ., et al. 2000. Alcohol. 20: 87-91. PMID: 10680722
- Central nervous system effects of thyrotropin-releasing hormone and its analogues: opportunities and perspectives for drug discovery and development. | Prokai, L. 2002. Prog Drug Res. 59: 133-69. PMID: 12458966
- The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics. | Gary, KA., et al. 2003. J Pharmacol Exp Ther. 305: 410-6. PMID: 12606661
- Thyrotropin-releasing hormone administration does not affect seizure threshold during electroconvulsive therapy. | Zervas, IM., et al. 2003. J ECT. 19: 136-8. PMID: 12972982
- Mice lacking the thyrotropin-releasing hormone gene: what do they tell us? | Yamada, M., et al. 2003. Thyroid. 13: 1111-21. PMID: 14751031
- Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2. | Kaur, N., et al. 2005. J Med Chem. 48: 6162-5. PMID: 16162016
- Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry. | Chambery, A., et al. 2010. Amino Acids. 38: 1031-41. PMID: 19526311
- Cardiac delivery of interference RNA for thyrotropin-releasing hormone inhibits hypertrophy in spontaneously hypertensive rat. | Jankowski, M. 2011. Hypertension. 57: 26-8. PMID: 21135355
- Thyrotropin-releasing hormone and its analogs accelerate wound healing. | Nie, C., et al. 2014. J Surg Res. 189: 359-65. PMID: 24713470
- Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. | Meena, CL., et al. 2016. Eur J Med Chem. 111: 72-83. PMID: 26854379
- Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide. | Kobayashi, N., et al. 2021. Chem Pharm Bull (Tokyo). 69: 314-324. PMID: 33790077
- Role of the thyrotropin-releasing hormone of the limbic system in mood and eating regulation. | Alvarez-Salas, E., et al. 2022. J Integr Neurosci. 21: 47. PMID: 35364635
- β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin. | Drastichova, Z., et al. 2022. Cells. 11: PMID: 35563779
Activator of:
RASL11A, and TRPV3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thyrotropin-Releasing Hormone, 10 mg | sc-481830A | 10 mg | $86.00 | |||
Thyrotropin-Releasing Hormone, 50 mg | sc-481830 | 50 mg | $156.00 | |||
Thyrotropin-Releasing Hormone, 100 mg | sc-481830B | 100 mg | $284.00 | |||
Thyrotropin-Releasing Hormone, 250 mg | sc-481830C | 250 mg | $664.00 |