Molecular structure of Thyroid Hormone Receptor Antagonist, 1-850, CAS Number: 251310-57-3
Thyroid Hormone Receptor Antagonist, 1-850 (CAS 251310-57-3)
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Alternate Names:
TR Antagonist; 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
Application:
Thyroid Hormone Receptor Antagonist, 1-850 is a selective and high-affinity thyroid hormone receptor (TR) antagonist
CAS Number:
251310-57-3
Purity:
≥95%
Molecular Weight:
463.42
Molecular Formula:
C21H20F3N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which acts as a selective and high-affinity thyroid receptor antagonist (IC50 = 1.5 muM in HeLa cells). It is shown to block T3- (L-triiodothyronine) mediated interaction of TRalpha with nuclear receptor coactivator (NRC) as well as prevent the stimulation of gene expression. It exerts no effect on the retinoic acid receptor alpha (RARalpha) activity.
Thyroid Hormone Receptor Antagonist, 1-850 (CAS 251310-57-3) References
- Thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of Rho. | Zvibel, I., et al. 2010. Lab Invest. 90: 674-84. PMID: 20231820
- Regulation of early spontaneous network activity and GABAergic neurons development by thyroid hormone. | Westerholz, S., et al. 2010. Neuroscience. 168: 573-89. PMID: 20338226
- 3,5-di-iodothyronine stimulates tilapia growth through an alternate isoform of thyroid hormone receptor β1. | Navarrete-Ramírez, P., et al. 2014. J Mol Endocrinol. 52: 1-9. PMID: 24031088
- Thyroid hormone response element half-site organization and its effect on thyroid hormone mediated transcription. | Paquette, MA., et al. 2014. PLoS One. 9: e101155. PMID: 24971931
- L-thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1. | Dekkers, BG., et al. 2015. Am J Physiol Lung Cell Mol Physiol. 308: L301-6. PMID: 25480330
- Thyroid Hormone Receptors Predict Prognosis in BRCA1 Associated Breast Cancer in Opposing Ways. | Heublein, S., et al. 2015. PLoS One. 10: e0127072. PMID: 26029931
- Triiodothyronine regulates cell growth and survival in renal cell cancer. | Czarnecka, AM., et al. 2016. Int J Oncol. 49: 1666-78. PMID: 27632932
- Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. | Ma, H., et al. 2017. FASEB J. 31: 3425-3438. PMID: 28428265
- BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt. | Karandrea, S., et al. 2017. Environ Toxicol Pharmacol. 56: 29-34. PMID: 28869857
- Dioxin Exposure Alters Molecular and Morphological Responses to Thyroid Hormone in Xenopus laevis Cultured Cells and Prometamorphic Tadpoles. | Taft, JD., et al. 2018. Toxicol Sci. 161: 196-206. PMID: 29294139
- Finding the Right Fit: Highly Selective Binding by the Thyroid Hormone Receptor. | Schmidt, CW. 2020. Environ Health Perspect. 128: 64001. PMID: 32579035
- Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway. | Fernández, M., et al. 2020. Int J Mol Sci. 21: PMID: 33255695
- Identification of thyroid hormone/thyroid hormone receptor interaction based on aptamer-assisted protein-induced fluorescence enhancement. | Song, J., et al. 2021. Biosens Bioelectron. 191: 113444. PMID: 34175646
- Bisphenol S disrupts opsins gene expression and impairs the light-sensing function via antagonizing TH-TRβ signaling pathway in zebrafish larvae. | Wei, S., et al. 2023. Food Chem Toxicol. 172: 113588. PMID: 36574878
Inhibitor of:
Thyroid Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thyroid Hormone Receptor Antagonist, 1-850, 1 mg | sc-222357A | 1 mg | $77.00 | |||
Thyroid Hormone Receptor Antagonist, 1-850, 5 mg | sc-222357 | 5 mg | $96.00 | |||
Thyroid Hormone Receptor Antagonist, 1-850, 10 mg | sc-222357B | 10 mg | $132.00 |