Thy-1/CD90 Antibody (AF-9): sc-59396
- Thy-1/CD90 Antibody (AF-9) is a mouse monoclonal IgG1, cited in 7 publications, provided at 100 µg/ml
- raised against purified Thy-1 of human origin
- recommended for detection of Thy-1 of mouse, rat and human origin by WB, IP, IF and FCM
- See Thy-1/CD90 (aTHy-1A1): sc-53456 for Thy-1/CD90 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Thy-1/CD90 Antibody (AF-9). This work is in progress.
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Thy-1 Antibody (AF-9) is a mouse monoclonal IgG1 antibody that detects Thy-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Thy-1 is a phosphatidyl-anchored cell surface glycoprotein that plays a crucial role in cell adhesion and signaling, particularly in the context of hematopoietic stem cells. Thy-1 presence on the surface of these cells is vital for their identification and isolation, as Thy-1 helps distinguish them from other cell types within the bone marrow microenvironment. Thy-1 interaction with various ligands and receptors is essential for maintaining stem cell properties and regulating immune responses, making Thy-1 a significant marker in studies related to graft versus host disease and post-transplant autoreactivity. Anti-Thy-1 antibody (AF-9) enables researchers to effectively explore the dynamics of stem cell populations and their implications in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thy-1/CD90 Antibody (AF-9) References:
- Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum. | Saalbach, A., et al. 1999. Cell Tissue Res. 298: 307-15. PMID: 10571119
- Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. | Hagood, JS., et al. 2005. Am J Pathol. 167: 365-79. PMID: 16049324
- Thy-1 is expressed in hepatic myofibroblasts and not oval cells in stem cell-mediated liver regeneration. | Dezso, K., et al. 2007. Am J Pathol. 171: 1529-37. PMID: 17884967
- Thy-1 mRNA destabilization by norepinephrine a 3' UTR cAMP responsive decay element and involves RNA binding proteins. | LaJevic, MD., et al. 2010. Brain Behav Immun. 24: 1078-88. PMID: 20412850
- Up-regulation of thy-1 promotes invasion and metastasis of hepatocarcinomas. | Cheng, BQ., et al. 2012. Asian Pac J Cancer Prev. 13: 1349-53. PMID: 22799330
- Thy-1 expression, a possible marker of early myofibroblast development, in renal tubulointerstitial fibrosis induced in rats by cisplatin. | Yuasa, T., et al. 2013. Exp Toxicol Pathol. 65: 651-9. PMID: 22884260
- Expression of the Thy-1 gene and Thy-1-derived fusion genes in transgenic mice. | Evans, GA. and Chen, S. 1989. Mol Biol Med. 6: 549-56. PMID: 2576809
- Serially transplantable mammary epithelial cells express the Thy-1 antigen. | Lobo, NA., et al. 2018. Breast Cancer Res. 20: 121. PMID: 30305179
- Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. | Borrello, MA. and Phipps, RP. 1996. Cell Immunol. 173: 198-206. PMID: 8912877
- Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. | Fujita, N., et al. 1997. Exp Cell Res. 232: 400-6. PMID: 9168818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thy-1/CD90 Antibody (AF-9) | sc-59396 | 100 µg/ml | $322.00 |