THTR1 Antibody (R-5): sc-100649

THTR1 Antibody (R-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects THTR1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-THTR1 antibody (R-5) is available as the non-conjugated form. THTR1, encoded by the SLC19A2 gene, plays a crucial role in cellular uptake of thiamine, a vital micronutrient necessary for various metabolic processes, including energy production and neurotransmitter synthesis. THTR1 is primarily located in the plasma membrane of cells in the liver and other tissues, where THTR1 facilitates thiamine transport into cells, ensuring cellular requirements for this essential vitamin are met. THTR1′s function is particularly important because thiamine deficiency can lead to severe neurological and cardiovascular disorders, highlighting the significance of effective thiamine transport in maintaining cellular health. Thiamine uptake by THTR1 is influenced by several factors, including sodium levels, pH, and structural analogues, which can either enhance or inhibit transport activity. Mutations in the SLC19A2 gene can disrupt THTR1 functionality, leading to conditions such as thiamine-responsive megaloblastic anemia, underscoring THTR1′s importance in human health.

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THTR1 Antibody (R-5) References:

1. Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function.  |  Liu, XY., et al. 2003. Biochem J. 369: 31-7. PMID: 12227830
2. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms.  |  Subramanian, VS., et al. 2003. J Biol Chem. 278: 3976-84. PMID: 12454006
3. Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells.  |  Said, HM., et al. 2002. Biochim Biophys Acta. 1567: 106-12. PMID: 12488043
4. Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters.  |  Oyewumi, MO., et al. 2003. Bioconjug Chem. 14: 404-11. PMID: 12643751
5. In vitro and in vivo characterization of the minimal promoter region of the human thiamin transporter SLC19A2.  |  Reidling, JC. and Said, HM. 2003. Am J Physiol Cell Physiol. 285: C633-41. PMID: 12900388
6. Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function.  |  Boulware, MJ., et al. 2003. Biochem J. 376: 43-8. PMID: 14602044
7. Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family.  |  Baron, D., et al. 2003. Eur J Biochem. 270: 4469-77. PMID: 14622275

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-THTR1 Antibody (R-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-THTR1 Antibody (R-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

THTR1 Antibody (R-5) Specifications

Alternate Product Name: THTR1

Product Clone Name: R-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 209-286

Epitope Target: THTR1

Epitope Species: human

Product Reactivity/Detection: THTR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for THTR1 Antibody (R-5): N/A