Date published: 2026-5-25

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Thromboxane B1 (CAS 64626-32-0)

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Alternate Names:
9,11,15-trihydroxy-thrombox-13-en-1-oic acid; TXB1
Application:
Thromboxane B1 is specific biomarker for prior ethanol abuse
CAS Number:
64626-32-0
Molecular Weight:
372.49
Molecular Formula:
C20H36O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Thromboxane B1, with the CAS number 64626-32-0, is a biologically inactive metabolite of Thromboxane A2 (TXA2), a compound involved in the modulation of platelet aggregation and vasoconstriction. In research contexts, Thromboxane B1 is primarily used as a marker to study the metabolic pathways and enzymatic reactions related to the synthesis and breakdown of TXA2. This compound allows scientists to trace the activity of TXA2 in various physiological and biochemical processes without the complications associated with its highly reactive and short-lived precursor. Thromboxane B1′s stability compared to TXA2 makes it particularly useful in experiments designed to understand the role of thromboxanes in cellular signaling and their overall impact on vascular tone and hemostasis in non-medical scenarios. Researchers employ techniques such as mass spectrometry and chromatography to quantify the levels of Thromboxane B1 in biological samples, providing insights into the efficacy of different biochemical pathways and the influence of environmental or genetic factors on these processes. Moreover, studies involving Thromboxane B1 contribute significantly to the field of biochemistry, where understanding the detailed mechanisms of eicosanoid action can lead to advances in the development of biochemical assays and the optimization of industrial processes that involve lipid-derived mediators.


Thromboxane B1 (CAS 64626-32-0) References

  1. Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.  |  Levin, G., et al. 2002. Biochem J. 365: 489-96. PMID: 11939906
  2. Biosynthesis of thromboxane B2: assay, isolation, and properties of the enzyme system in human platelets.  |  Ho, PP., et al. 1976. Prostaglandins. 12: 951-70. PMID: 12539
  3. An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3.  |  Park, WJ., et al. 2009. J Lipid Res. 50: 1195-202. PMID: 19202133
  4. A monoclonal anti-thromboxane B2 antibody.  |  Reinke, M. and Brune, K. 1988. FEBS Lett. 232: 46-50. PMID: 3130275
  5. Valorization of avocado seeds with antioxidant capacity using pressurized hot water extraction.  |  Ong, ES., et al. 2022. Sci Rep. 12: 13036. PMID: 35906278
  6. Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol.  |  Manku, MS., et al. 1979. Prostaglandins Med. 3: 119-28. PMID: 552099
  7. Gas-liquid chromatography-mass spectrometry of thromboxane B2 and its detection in semen and human aorta by selected ion monitoring.  |  Smith, AG., et al. 1977. J Chromatogr. 142: 533-47. PMID: 562354
  8. Dihomogammalinolenic acid, but not eicosapentaenoic acid, activates washed human platelets.  |  Siess, W., et al. 1984. Biochim Biophys Acta. 801: 265-76. PMID: 6089912
  9. Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets.  |  Best, LC., et al. 1981. Biochem Pharmacol. 30: 635-7. PMID: 6268118
  10. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat.  |  Chiabrando, C., et al. 1994. Prostaglandins. 47: 409-22. PMID: 7938613

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thromboxane B1, 1 mg

sc-205525
1 mg
$130.00

Thromboxane B1, 5 mg

sc-205525A
5 mg
$584.00