Thrombospondin 1 Antibody (A6.1): sc-59887

Thrombospondin 1 Antibody (A6.1) is a mouse monoclonal IgG1 kappa light chain antibody engineered to specifically recognize Thrombospondin 1 (TSP-1). Anti-Thrombospondin 1 antibody (A6.1) is raised against reduced and alkylated human Thrombospondin 1. Thrombospondin 1 is a pivotal extracellular glycoprotein involved in crucial cell-to-cell and cell-to-matrix signaling pathways, which are essential for processes such as platelet aggregation, cellular adhesion, migration, and the regulation of tissue development and repair. By mediating interactions between cells and the extracellular matrix, Thrombospondin 1 plays a significant role in inhibiting angiogenesis, regulating wound healing, and contributing to the metastatic progression of cancer cells, highlighting its importance in both physiological and pathological contexts. Thrombospondin 1 monoclonal antibody (A6.1) is recommended for use across a wide range of applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), and demonstrates robust species reactivity with Thrombospondin 1 from mouse, rat, human, equine, bovine, porcine, and canine origins. Anti-Thrombospondin 1 antibody (A6.1) does not cross-react with other proteins such as Fibronectin, fibrinogen, or Von Willebrand factor, ensuring reliable and accurate detection of Thrombospondin 1. Anti-Thrombospondin 1 antibody (A6.1) is recommended for researchers investigating the multifaceted roles of Thrombospondin 1 in maintaining cellular homeostasis, responding to tissue injury, and understanding its involvement in various disease mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Thrombospondin 1 Antibody (A6.1) References:

1. Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.  |  O'Rourke, KM., et al. 1992. J Biol Chem. 267: 24921-4. PMID: 1459996
2. Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.  |  LaBell, TL., et al. 1992. Genomics. 12: 421-9. PMID: 1559694
3. Physiology of thrombospondin.  |  Mosher, DF. 1990. Annu Rev Med. 41: 85-97. PMID: 1691903
4. A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome.  |  Bornstein, P., et al. 1991. J Biol Chem. 266: 12821-4. PMID: 1712771
5. Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration.  |  Housset, M. and Sennlaub, F. 2015. J Ocul Pharmacol Ther. 31: 406-12. PMID: 26062001
6. Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria.  |  Binsker, U., et al. 2019. J Innate Immun. 11: 303-315. PMID: 30814475
7. Thrombospondin-1 induction and VEGF reduction by proteasome inhibition.  |  Bardag-Gorce, F., et al. 2023. Heliyon. 9: e13397. PMID: 36846655
8. Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.  |  Pei, L., et al. 2024. Basic Res Cardiol. 119: 169-192. PMID: 38147128
9. Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth.  |  Arber, S. and Caroni, P. 1995. J Cell Biol. 131: 1083-94. PMID: 7490284
10. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues.  |  Qabar, A., et al. 1995. J Biol Chem. 270: 12725-9. PMID: 7759526
11. The functions of thrombospondin and its involvement in physiology and pathophysiology.  |  Lahav, J. 1993. Biochim Biophys Acta. 1182: 1-14. PMID: 8347680
12. Thrombospondin-1.  |  Adams, JC. 1997. Int J Biochem Cell Biol. 29: 861-5. PMID: 9304800

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Thrombospondin 1 Antibody (A6.1) has 66 citations in a variety of scientific publications.

Primary antibodies like Anti-Thrombospondin 1 Antibody (A6.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Thrombospondin 1 Antibody (A6.1) Specifications

Alternate Product Name: Thrombospondin

Product Clone Name: A6.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Thrombospondin 1

Epitope Species: human

Product Reactivity/Detection: reduced and non-reduced Thrombospondin 1

Species Reactivity/Detection: mouse, rat, human, equine, bovine, porcine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 66 citations in various scientific publications

Available Conjugates/Forms for Thrombospondin 1 Antibody (A6.1): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790