Thrombin Antibody (GMA-020): sc-65961
- Thrombin Antibody (GMA-020) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against Thrombin of Thrombin of prothrombin
- recommended for detection of Thrombin of human origin by WB
- See Thrombin (F-1): sc-271449 for Thrombin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Thrombin Antibody (GMA-020). This work is in progress.
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Thrombin Antibody (GMA-020) is a mouse monoclonal IgG1 antibody that detects Thrombin in human samples through western blotting (WB). Thrombin, also known as Coagulation Factor 2, plays a pivotal role in the hemostatic process following tissue injury by being the first serine protease activated in the coagulation cascade, where Thrombin is generated from the proteolytic cleavage of Prothrombin. This enzyme not only facilitates the conversion of fibrinogen to fibrin, leading to clot formation, but also has significant implications in various physiological processes, including cellular mitogenesis, tumor growth, and metastasis. Importantly, Thrombin is involved in the regulation of vascular integrity during both development and postnatal life, making Thrombin crucial for maintaining proper blood vessel function. Additionally, during wound healing, Thrombin coordinates the activity of connective tissue proteins by stimulating fibroblast production of procollagen, thereby promoting tissue repair and regeneration. Anti-Thrombin antibody (GMA-020) is an essential tool for researchers studying coagulation processes, vascular biology, and wound healing mechanisms.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thrombin Antibody (GMA-020) References:
- Thrombin and platelet activation. | Brass, LF. 2003. Chest. 124: 18S-25S. PMID: 12970120
- Age-dependency of thrombin generation. | Hemker, HC. and Al Dieri, R. 2006. Thromb Haemost. 95: 756-7. PMID: 16676062
- Thrombin physiology and pathophysiology. | Licari, LG. and Kovacic, JP. 2009. J Vet Emerg Crit Care (San Antonio). 19: 11-22. PMID: 19691582
- Direct thrombin inhibitors. | O'Brien, PJ. and Mureebe, L. 2012. J Cardiovasc Pharmacol Ther. 17: 5-11. PMID: 21335484
- Thrombin generation and atherosclerosis. | Kalz, J., et al. 2014. J Thromb Thrombolysis. 37: 45-55. PMID: 24241912
- Thrombin-cellular interactions. | Shuman, MA. 1986. Ann N Y Acad Sci. 485: 228-39. PMID: 3032044
- The role of thrombin in haemostasis. | Al-Amer, OM. 2022. Blood Coagul Fibrinolysis. 33: 145-148. PMID: 35239615
- Shining a light on thrombin activation. | Spiegel, PC. 2022. Blood. 139: 3451-3453. PMID: 35708725
- Thrombin and Thrombin-Incorporated Biomaterials for Disease Treatments. | Zhang, QD., et al. 2024. Adv Healthc Mater. 13: e2302209. PMID: 37897228
- Aptamer biosensors for thrombin. | Oushyani Roudsari, Z., et al. 2025. Clin Chim Acta. 565: 119976. PMID: 39321910
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombin Antibody (GMA-020) | sc-65961 | 100 µg/ml | $316.00 |