Molecular structure of Thiostrepton, CAS Number: 1393-48-2
Thiostrepton (CAS 1393-48-2)
See product citations (10)
Alternate Names:
Thiostrepton also known as Bryamycin; Thiactin; Alaninamide; A-8506; Antibiotic 6761-31; Antibiotic A-8506; Antibiotic X-146; X-146; Gargon
Application:
Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties
CAS Number:
1393-48-2
Molecular Weight:
1664.88
Molecular Formula:
C72H85N19O18S5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. It exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, overexpressed in many malignancies. Additionally, it is an inhibitor of FOXM1.
Thiostrepton (CAS 1393-48-2) References
- Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. | Chiu, ML., et al. 1999. J Biol Chem. 274: 20578-86. PMID: 10400688
- Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. | Rodnina, MV., et al. 1999. Proc Natl Acad Sci U S A. 96: 9586-90. PMID: 10449736
- Novel mutants of 23S RNA: characterization of functional properties. | Saarma, U. and Remme, J. 1992. Nucleic Acids Res. 20: 3147-52. PMID: 1377819
- Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment. | Blanco, G., et al. 1992. Gene. 112: 59-65. PMID: 1551599
- Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus. | Malina, H. and Robert-Gero, M. 1992. Appl Environ Microbiol. 58: 895-9. PMID: 1575490
- The binding of thiostrepton to 23S ribosomal RNA. | Thompson, J. and Cundliffe, E. 1991. Biochimie. 73: 1131-5. PMID: 1720665
- Thiostrepton inhibition of tRNA delivery to the ribosome. | Gonzalez, RL., et al. 2007. RNA. 13: 2091-7. PMID: 17951333
- Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. | Kwok, JM., et al. 2008. Mol Cancer Ther. 7: 2022-32. PMID: 18645012
- Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton. | Ryan, PC., et al. 1991. J Mol Biol. 221: 1257-68. PMID: 1942050
- Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome. | Miller, SP. and Bodley, JW. 1991. Nucleic Acids Res. 19: 1657-60. PMID: 2027773
- Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA. | Kutay, UR., et al. 1990. Biochim Biophys Acta. 1050: 193-6. PMID: 2169893
- Construction of a series of pSAM2-based integrative vectors for use in actinomycetes. | Smokvina, T., et al. 1990. Gene. 94: 53-9. PMID: 2227452
- Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex. | Bodley, JW., et al. 1970. Biochem Biophys Res Commun. 41: 1406-11. PMID: 5487868
- The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A. | Rosendahl, G. and Douthwaite, S. 1994. Nucleic Acids Res. 22: 357-63. PMID: 8127673
Inhibitor of:
2810403A07Rik, ACTBL2, Bag-1, C8orf79_6430573F11Rik, Cdc20B, Cdc5L, CENP-F, Cks1, Cnbp2, COL11A1, Collagen Type IV, EF-G1, EULIR, FDXACB1, FOXM1, FOXQ1, HCFC1R1, HNF-1α, HoxA7, LOC345643, LOC729978, MAD2_Mad2, Miner2, MLZE, MRP-L19, MYADML2, NIP7, Nop10, NusA, PP2A-B55-α, Ribosomal Protein L28, Ribosomal Protein L32, Ribosomal Protein L6, Ribosomal Protein LP0, UFD2, and Vmn2r112.Activator of:
DDX51, FOXM1, RNA pol σ E, and Rrp6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiostrepton, 1 g | sc-203412 | 1 g | $115.00 | |||
Thiostrepton, 5 g | sc-203412A | 5 g | $415.00 |