Molecular structure of Thioridazine Hydrochloride, CAS Number: 130-61-0
Thioridazine Hydrochloride (CAS 130-61-0)
Alternate Names:
10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Application:
Thioridazine Hydrochloride is a D2DR, D4DR, and calcium channel protein inhibitor
CAS Number:
130-61-0
Purity:
≥98%
Molecular Weight:
407.00
Molecular Formula:
C21H26N2S2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thioridazine·HCl functions as a dopamine receptor antagonist, particularly targeting D2 receptors. It acts by blocking the binding of dopamine to these receptors, thereby inhibiting the transmission of dopamine signaling in the central nervous system. Thioridazine·Hcl′s mechanism of action involves disrupting the balance of neurotransmitters in the brain, leading to altered neuronal activity. By interfering with dopamine signaling, Thioridazine·HCl can impact various physiological and behavioral processes regulated by dopamine, influencing motor control, emotional responses, and cognitive functions. At the molecular level, Thioridazine·HCl exerts its effects by binding to the D2 receptors and preventing the activation of downstream signaling pathways.
Thioridazine Hydrochloride (CAS 130-61-0) References
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- Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment. | Vonvoigtlander, PF., et al. 1975. J Pharmacol Exp Ther. 193: 88-94. PMID: 166158
- Cytogenetic effect of thioridazine hydrochloride in mice and in human lymphocyte chromosomes. | Suryanarayana, A. 1991. Ceylon Med J. 36: 102-5. PMID: 1934152
- Calcium-antagonist drugs. Receptor interactions that clarify therapeutic effects. | Snyder, SH. and Reynolds, IJ. 1985. N Engl J Med. 313: 995-1002. PMID: 2413355
- Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle. | Jensen, AS., et al. 2015. Eur J Pharmacol. 747: 7-12. PMID: 25449032
- An optical sensor with specific binding sites for the detection of thioridazine hydrochloride based on ZnO-QDs coated with molecularly imprinted polymer. | Ensafi, AA., et al. 2019. Spectrochim Acta A Mol Biomol Spectrosc. 206: 460-465. PMID: 30172874
- Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis. | Song, Y., et al. 2020. Cell Cycle. 19: 3521-3533. PMID: 33315498
- Thioridazine and EKG anomalies. | Hine, B., et al. 1979. Experientia. 35: 1631-2. PMID: 520480
- The effect of thioridazine hydrochloride and chlorpromazine on the electrocardiogram. | Huston, JR. and Bell, GE. 1966. JAMA. 198: 134-8. PMID: 5953158
- High-performance liquid chromatographic determination of chloropromazine and thioridazine hydrochlorides in pharmaceutical formulations. | Mehta, AC. 1981. Analyst. 106: 1119-22. PMID: 7304993
- D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs. | Roth, BL., et al. 1995. Psychopharmacology (Berl). 120: 365-8. PMID: 8524985
- Influence of processing on the stability and release properties of biodegradable microspheres containing thioridazine hydrochloride. | O'Donnell, PB. and McGinity, JW. 1998. Eur J Pharm Biopharm. 45: 83-94. PMID: 9689539
Inhibitor of:
ACOT11, ACOXL, Calcium Channel Protein, CNOT7, COQ5, D2DR, D4DR, EDF1, ESAT6, GNPAT, NDUFB3, PP2A-B55-δ, Sall4, and Sp4.Activator of:
RV2623 Dormancy Regulon, and Stim2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thioridazine Hydrochloride, 5 mg | sc-201149A | 5 mg | $20.00 | |||
Thioridazine Hydrochloride, 1 g | sc-201149 | 1 g | $48.00 | |||
Thioridazine Hydrochloride, 5 g | sc-201149B | 5 g | $102.00 | |||
Thioridazine Hydrochloride, 25 g | sc-201149C | 25 g | $408.00 | |||
Thioridazine Hydrochloride, 100 g | sc-201149D | 100 g | $1224.00 |