Thionicotinamide adenine dinucleotide (CAS 4090-29-3)

Thionicotinamide adenine dinucleotide is a chemically modified variant of Nicotinamide Adenine Dinucleotide (NAD+). As a research tool, thionicotinamide adenine dinucleotide is used as a probe to study the interaction between NAD+-dependent enzymes and their substrates or inhibitors. The sulfur modification alters how the molecule interacts with these enzymes compared to NAD+, providing insights into the enzyme′s active site and how it processes various molecules. This information is for understanding the fundamental mechanisms of enzymatic reactions, including those involved in energy production and conversion within cells. Furthermore, due to its unique chemical structure, thionicotinamide adenine dinucleotide can serve as an important agent in the development of fluorescent or colorimetric assays. These assays are designed to measure enzyme activity, detect specific biomolecules, or monitor metabolic processes in real-time, contributing significantly to the toolkit available for biochemical and biophysical studies.